Research Output

2000

Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

Rotella, D. P., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L. & Mitchison, T. J., 1 Apr 2000, In : Chemtracts. 13, 4, p. 256-258 3 p.

Research output: Contribution to journalComment/debate

Structural effects of impurities in Ba4Er2Cu7O(15-δ): Incorporation of Au and of Al

Siegrist, T., Schneemeyer, L. F., Van Dover, R. B. & Waszczak, J. V., 1 Jan 2000, In : Journal of Solid State Chemistry. 150, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

1999

1,2,3,4,5,6,7,8-Octahydroanthracene-9,10-dicarbonitrile at 172, 216, 256, and 297 K

Britton, D., DeSilva, S. A. & Gassman, P. G., 1 Jan 1999, In : Journal of Chemical Crystallography. 29, 8, p. 949-953 5 p.

Research output: Contribution to journalArticle

Ab initio molecular orbital study of the conformational energies of 3- alkyltetrahydro-2H-pyrans

Freeman, F., Kasner, M. & Hehre, W. J., 17 Sep 1999, In : Journal of Molecular Structure: THEOCHEM. 487, 1-2, p. 87-105 19 p.

Research output: Contribution to journalArticle

15 Scopus citations

Advanced amorphous dielectrics for embedded capacitors

Alers, G. B., van Dover, R. B., Schneemeyer, L. F., Stirling, L., Sung, C. Y., Diodato, P. W., Liu, R., Wong, Y. H., Fleming, R. M., Lang, D. V. & Chang, J. P., 1 Dec 1999, In : Technical Digest - International Electron Devices Meeting. p. 797-800 4 p.

Research output: Contribution to journalConference article

8 Scopus citations

A high-throughput search for electronic materials-thin-film dielectrics

Van Dover, R. B., Schneemeyer, L. F., Fleming, R. M. & Huggins, H. A., 1 Jan 1999, In : Biotechnology and Bioengineering. 61, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

CO photolysis of cytochrome oxidase investigated by ps resonance Raman spectroscopy

Schelvis, J. P. M., Varotsis, C., Deinum, G. & Babcock, G. T., 1 Jan 1999, In : Laser Chemistry. 19, 1-4, p. 223-225 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Crystallization and initial X-ray analysis of rabbit mature sterol carrier protein 2

Choinowski, T., Dyer, J. H., Maderegger, B., Winterhalter, K. H., Hauser, H. & Piontek, K., 1 Aug 1999, In : Acta Crystallographica Section D: Biological Crystallography. 55, 8, p. 1478-1480 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J. J., Peterson, P. A. & Fung-Leung, W. P., 5 Apr 1999, In : Journal of Experimental Medicine. 189, 7, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

Drug discovery and development

Finney, N., Ghosh, S., Hirst, J., Norman, P., Rotella, D. & Williams, M., 14 Apr 1999, In : Current Opinion in Drug Discovery and Development. 2, 2, p. 71-80 10 p.

Research output: Contribution to journalReview article

Folding dynamics of single GCN-4 peptides by fluorescence resonant energy transfer confocal microscopy

Jia, Y., Talaga, D. S., Lau, W. L., Lu, H. S. M., DeGrado, W. F. & Hochstrasser, R. M., 1 Aug 1999, In : Chemical Physics. 247, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

149 Scopus citations

High dielectric constant Hf-Sn-Ti-O thin films

Schneemeyer, L. F., Van Dover, R. B. & Fleming, R. M., 27 Sep 1999, In : Applied Physics Letters. 75, 13, p. 1967-1969 3 p.

Research output: Contribution to journalArticle

53 Scopus citations

High dielectric constant Hf-Ti-Sn-O off-axis cosputtered films

Schneemeyer, L. F., Van Dover, R. B. & Fleming, R. M., 1 Jan 1999, In : Materials Research Society Symposium - Proceedings. 541, p. 567-572 6 p.

Research output: Contribution to journalConference article

Improved properties of TaOx films doped with Al and N

Van Dover, R. B., Schneemeyer, L. F., Fleming, R. M. & Werder, D. J., 1 Jan 1999, In : Materials Research Society Symposium - Proceedings. 541, p. 561-566 6 p.

Research output: Contribution to journalConference article

1 Scopus citations

Lipoic acid biosynthesis: LipA is an iron-sulfur protein

Busby, R. W., Schelvis, J. P. M., Yu, D. S., Babcock, G. T. & Marletta, M. A., 19 May 1999, In : Journal of the American Chemical Society. 121, 19, p. 4706-4707 2 p.

Research output: Contribution to journalArticle

71 Scopus citations

Origin of the transient electron paramagnetic resonance signals in DNA photolyase

Gindt, Y. M., Vollenbroek, E., Westphal, K., Sackett, H., Sancar, A. & Babcock, G. T., 30 Mar 1999, In : Biochemistry. 38, 13, p. 3857-3866 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

p38α Mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

Schafer, P. H., Wadsworth, S. A., Wang, L. & Siekierka, J. J., 15 Jun 1999, In : Journal of Immunology. 162, 12, p. 7110-7119 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Photoaffinity labeling of oxidosqualene cyclase and squalene cyclase by a benzophenone-containing inhibitor

Abe, I., Zheng, Y. F., Prestwich, G. D. & Rotella, D. P., 1 Jan 1999, In : Chemtracts. 12, 7, p. 483-486 4 p.

Research output: Contribution to journalComment/debate

Rank-order of potencies for inhibition of the secretion of Aβ40 and Aβ42 suggests that both are generated by a single γ-secretase

Durkin, J. T., Murthy, S., Husten, E. J., Trusko, S. P., Savage, M. J., Rotella, D. P., Greenberg, B. D. & Siman, R., 16 Jul 1999, In : Journal of Biological Chemistry. 274, 29, p. 20499-20504 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic

Rosen, H., Hadju, R., Silver, L., Kropp, H., Dorso, K., Kohler, J., Sundelof, J. G., Huber, J., Hammond, G. G., Jackson, J. J., Gill, C. J., Thompson, R., Pelak, B. A., Epstein-Toney, J. H., Lankas, G., Wilkening, R. R., Wildonger, K. J., Blizzard, T. A., DiNinno, F. P., Ratcliffe, R. W. & 4 others, Heck, J. V., Kozarich, J. W., Hammond, M. L. & Rotella, D. P., 1 Aug 1999, In : Chemtracts. 12, 9, p. 675-678 4 p.

Research output: Contribution to journalComment/debate

Resistive upper critical fields and irreversibility lines of optimally doped high-Tc cuprates

Ando, Y., Boebinger, G. S., Passner, A., Schneemeyer, L. F., Kimura, T., Okuya, M., Watauchi, S., Shimoyama, J., Kishio, K., Tamasaku, K., Ichikawa, N. & Uchida, S., 1 Jan 1999, In : Physical Review B - Condensed Matter and Materials Physics. 60, 17, p. 12475-12479 5 p.

Research output: Contribution to journalArticle

114 Scopus citations

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

Wadsworth, S. A., Cavender, D. E., Beers, S. A., Lalan, P., Schafer, P. H., Malloy, E. A., Wu, W., Fahmy, B., Olini, G. C., Davis, J. E., Pellegrino-Gensey, J. L., Wachter, M. P. & Siekierka, J. J., 1 Nov 1999, In : Journal of Pharmacology and Experimental Therapeutics. 291, 2, p. 680-687 8 p.

Research output: Contribution to journalArticle

148 Scopus citations

Scanning tunneling spectroscopy of NbSe2-Au proximity junctions

Truscott, A. D., Dynes, R. C. & Schneemeyer, L. F., 1 Jan 1999, In : Physical Review Letters. 83, 5, p. 1014-1017 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural dynamics in the guanylate cyclase heme pocket after CO photolysis

Schelvis, J. P. M., Kim, S., Zhao, Y., Marletta, M. A. & Babcock, G. T., 18 Aug 1999, In : Journal of the American Chemical Society. 121, 32, p. 7397-7400 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synthesis of l-4,4-difluoroglutamic acid via electrophilic difluorination of a lactam

Konas, D. W. & Coward, J. K., 30 Dec 1999, In : Organic Letters. 1, 13, p. 2105-2107 3 p.

Research output: Contribution to journalArticle

41 Scopus citations

T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-α production in a manner distinct from LPS activation of monocytes

Schafer, P. H., Wang, L., Wadsworth, S. A., Davis, J. E. & Siekierka, J. J., 15 Jan 1999, In : Journal of Immunology. 162, 2, p. 659-668 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Use of x-ray co-crystal structures and molecular modeling to design potent and selective nonpeptide inhibitors of cathepsin K

Rotella, D. P., Yamashita, D. S., Oh, H. J., Uzinskas, I. N., Erhard, K. F., Allen, A. C., Haltiwanger, R. C., Zhao, B., Smith, W. W., Abdel-Meguid, S. S., Alessio, K. D., Jansen, C. A., McQueney, M. S., Tomoszek, T. A., Levy, M. A. & Veber, D. F., 1 Apr 1999, In : Chemtracts. 12, 4, p. 272-275 4 p.

Research output: Contribution to journalComment/debate

1998

(9-Anthrylmethyl)bis(2-pyridylmethyl)-amine

De Silva, S. A., Whitener, M. A., Baron, D. E., Zavaleta, A., Isidor, E. V. & Allam, O., 15 Aug 1998, In : Acta Crystallographica Section C: Crystal Structure Communications. 54, 8, p. 1117-1119 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

3-[(2-Aminoethyl)iminomethyl]-4-hydroxybenzoic acid 0.28-hydrate

Whitener, M. A., De Freitas, C. B. & Zavaleta, A., 15 Aug 1998, In : Acta Crystallographica Section C: Crystal Structure Communications. 54, 8, p. 1119-1121 3 p.

Research output: Contribution to journalArticle

6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354): A potent and selective p38 kinase inhibitor [4]

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., Fahmy, B., Olini, G. C., Davis, J. E., Lee Pellegrino-Gensey, J., Schafer, P. H. & Siekierka, J. J., 23 Oct 1998, In : Journal of Medicinal Chemistry. 41, 22, p. 4196-4198 3 p.

Research output: Contribution to journalLetter

75 Scopus citations

Advanced dielectrics for gate oxide, DRAM and rf capacitors

van Dover, R. B., Fleming, R. M., Schneemeyer, L. F., Alers, G. B. & Werder, D. J., 1 Dec 1998, In : Technical Digest - International Electron Devices Meeting. p. 823-828 6 p.

Research output: Contribution to journalConference article

33 Scopus citations

Deposition of uniform Zr-Sn-Ti-O films by on-axis reactive sputtering

Van Dover, R. B. & Schneemeyer, L. F., 1 Sep 1998, In : IEEE Electron Device Letters. 19, 9, p. 329-331 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Detergent-salt resistance of LAP2α in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

Dechat, T., Gotzmann, J., Stockinger, A., Harris, C. A., Talle, M. A., Siekierka, J. J. & Foisner, R., 17 Aug 1998, In : EMBO Journal. 17, 16, p. 4887-4902 16 p.

Research output: Contribution to journalArticle

115 Scopus citations

Discovery of a useful thin-film dielectric using a composition-spread approach

Van Dover, R. B., Schneemeyer, L. F. & Fleming, R. M., 12 Mar 1998, In : Nature. 392, 6672, p. 162-164 3 p.

Research output: Contribution to journalArticle

316 Scopus citations

Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

Rotella, D. P., Bayburt, E. K., Capparelli, M. P., Carroll, B. J., Goldstein, R., Justice, M. R., Zhu, L., Hu, S., Melton, R. A., Freyer, L., Golding, R. L., Doughty, J. R., Spirito, S., Bloncuzzi, V., Wilson, D., Byrne, E. M., Ganu, V. & Parker, D. T., 1 Apr 1998, In : Chemtracts. 11, 4, p. 301-305 5 p.

Research output: Contribution to journalComment/debate

Growth of single crystal fibers for 1.3 μm optical amplifiers by the laser-heated pedestal growth method

Wang, L. H., Hon, M. H., Schneemeyer, L. F., Thomas, G. A. & Wilson, W. L., 1 Jan 1998, In : Materials Research Bulletin. 33, 12, p. 1793-1799 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of a receptor mediating absorption of dietary cholesterol in the intestine

Hauser, H., Dyer, J. H., Nandy, A., Vega, M. A., Werder, M., Bieliauskaite, E., Weber, F. E., Compassi, S., Gemperli, A., Boffelli, D., Wehrli, E., Schulthess, G. & Phillips, M. C., 22 Dec 1998, In : Biochemistry. 37, 51, p. 17843-17850 8 p.

Research output: Contribution to journalArticle

215 Scopus citations

Identification of histidine 105 in the β1 subunit of soluble guanylate cyclase as the heme proximal ligand

Zhao, Y., Schelvis, J. P. M., Babcock, G. T. & Marletta, M. A., 31 Mar 1998, In : Biochemistry. 37, 13, p. 4502-4509 8 p.

Research output: Contribution to journalArticle

149 Scopus citations

Identification of histidine 105 in the β1 subunit of soluble guanylate cyclase as the heme proximal ligand

Zhao, Y., Schelvis, J. P. M. & Bahcock, G. T., 1 Dec 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide 1-20 is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP2

Weber, F. E., Dyer, J. H., López García, F., Werder, M., Szyperski, T., Wüthrich, K. & Hauser, H., 28 Aug 1998, In : Cellular and Molecular Life Sciences. 54, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

Kanakaraj, P., Schafer, P. H., Cavender, D. E., Wu, Y., Ngo, K., Grealish, P. F., Wadsworth, S. A., Peterson, P. A., Siekierka, J. J., Harris, C. A. & Fung-Leung, W. P., 15 Jun 1998, In : Journal of Experimental Medicine. 187, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

171 Scopus citations

Irak requirement for optimal induction by IL-I of multiple signaling pathways

Kanakaraji, P., Schafer, P. H., Cavender, D., Ngo, K., Wul, Y., Grealish, F. F., Wadsworth, S. A., Peterson, P. A., Siekierka, J. J., Harris, C. A. & Fung-Leungl, W. P., 1 Dec 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

Luminescent Photofragments of (1,1,1,5,5,5-Hexafluoro-2,4-pentanedionato) Metal Complexes in the Gas Phase

Talaga, D. S., Hanna, S. D. & Zink, J. I., 1 Dec 1998, In : Inorganic Chemistry. 37, 12, p. 2880-2887 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Micro-transformer devices using thin-film electroplated deposition

Lotfi, A., Van Dover, R. B., Schneemeyer, L. & Steigerwald, M., 1 Jan 1998, PESC Record - IEEE Annual Power Electronics Specialists Conference. Anon (ed.). p. 1511-1515 5 p. (PESC Record - IEEE Annual Power Electronics Specialists Conference; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Novel biologically active nonpeptidic inhibitors of myristoyl-CoA:protein N-myristoyltransferase

Rotella, D. P., 1 Aug 1998, In : Chemtracts. 11, 9, p. 667-670 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase

Rotella, D. P., Bernstein, P. R., Bohnert, C. M., Brown, F. J., Bryant, C., Damewood, J. R., Early, R., Feeney, S. W., Edwards, P. D., Gomes, B., Hulsinger, J. M., Kosmider, B. J., Krell, R. D., Moore, G., Salcedo, T. W., Show, A., Silberstein, D. S., Steelman, G. B., Stein, M., Strimpler, A. & 5 others, Thomas, R. M., Vacek, E. P., Williams, J. C., Wolanin, D. J. & Woolson, S., 1 Jun 1998, In : Chemtracts. 11, 7, p. 546-549 4 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Potent inhibitors of the MAP kinase p38

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., Schafer, P. H. & Siekierka, J. J., 1 Dec 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 23, p. 3335-3340 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Resonance Raman characterization of the heme domain of soluble guanylate cyclase

Schelvis, J. P. M., Zhao, Y., Marletta, M. A. & Babcock, G. T., 17 Nov 1998, In : Biochemistry. 37, 46, p. 16289-16297 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

The development of novel and selective p56(lck) tyrosine kinase inhibitors

Bullington, J. L., Cameron, J. C., Davis, J. E., Dodd, J. H., Harris, C. A., Henry, J. R., Pellegrino-Gensey, J. L., Rupert, K. C. & Siekierka, J. J., 22 Sep 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 18, p. 2489-2494 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Yeast immunophilins: Purification and assay of yeast FKBP12

Wiederrecht, G. & Siekierka, J. J., 1 Jan 1998, In : Methods in Enzymology. 290, p. 74-84 11 p.

Research output: Contribution to journalArticle