• 1649 Citations
  • 21 h-Index
20052019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1649 Citations
  • 21 h-Index
  • 42 Article
  • 5 Review article
  • 3 Chapter
  • 1 Short survey
Filter
Article
Article

A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant

Bétry, C., Overstreet, D., Haddjeri, N., Pehrson, A. L., Bundgaard, C., Sanchez, C. & Mørk, A., 1 Jan 2015, In : Pharmacology Biochemistry and Behavior. 131, p. 136-142 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Acute effects of vortioxetine and duloxetine on resting-state functional connectivity in the awake rat

Pérez, P. D., Ma, Z., Hamilton, C., Sánchez, C., Mørk, A., Pehrson, A. L., Bundgaard, C. & Zhang, N., 1 Jan 2018, In : Neuropharmacology. 128, p. 379-387 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats

Prus, A. J., Vann, R. E., Rosecrans, J. A., James, J. R., Pehrson, A. L., O'Connell, M. M., Philibin, S. D. & Robinson, S. E., 1 Nov 2008, In : Pharmacology Biochemistry and Behavior. 91, 1, p. 150-154 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

Guilloux, J. P., Mendez-David, I., Alan, P., Guiard, B. P., Repérant, C., Orvoën, S., Gardier, A. M., Hen, R., Bjarke, E., Miller, S., Connie, S. & David, D. J., 1 Jan 2013, In : Neuropharmacology. 73, p. 147-159 13 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

Li, Y., Pehrson, A. L., Budac, D. P., Sánchez, C. & Gulinello, M., 1 Oct 2012, In : Behavioural Brain Research. 234, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation

Li, Y., Pehrson, A. L., Oosting, R. S., Gulinello, M., Olivier, B. & Sanchez, C., 15 Jul 2017, In : Neuropharmacology. 121, p. 89-99 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Brexpiprazole I: In vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

Maeda, K., Sugino, H., Akazawa, H., Amada, N., Shimada, J., Futamura, T., Yamashita, H., Ito, N., McQuade, R. D., Mørk, A., Pehrson, A. L., Hentzer, M., Nielsen, V., Bundgaard, C., Arnt, J., Stensbøl, T. B. & Kikuchi, T., Sep 2014, In : Journal of Pharmacology and Experimental Therapeutics. 350, 3, p. 589-604 16 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations

Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

Waller, J. A., Tamm, J. A., Abdourahman, A., Pehrson, A. L., Li, Y., Cajina, M. & Sánchez, C., 1 Feb 2017, In : European Neuropsychopharmacology. 27, 2, p. 192-203 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism

Leiser, S. C., Iglesias-Bregna, D., Westrich, L., Pehrson, A. L. & Sanchez, C., 24 Oct 2015, In : Journal of Psychopharmacology. 29, 10, p. 1092-1105 14 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Discriminative stimulus properties of 1.25 mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors

Prus, A. J., Wise, L. E., Pehrson, A. L., Philibin, S. D., Bang-Andersen, B., Arnt, J. & Porter, J. H., 1 Oct 2016, In : Brain Research. 1648, p. 298-305 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle

Prus, A. J., Philibin, S. D., Pehrson, A. L. & Porter, J. H., 1 Mar 2006, In : Behavioural Pharmacology. 17, 2, p. 185-194 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory

Bétry, C., Etiévant, A., Pehrson, A., Sánchez, C. & Haddjeri, N., 3 Apr 2015, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 58, p. 38-46 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats

Hlavacova, N., Li, Y., Pehrson, A., Sanchez, C., Bermudez, I., Csanova, A., Jezova, D. & Franklin, M., 2 Mar 2018, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 82, p. 332-338 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task

Prus, A. J., Philibin, S. D., Pehrson, A. L., Stephens, C. L., Cooper, R. N., Wise, L. E. & Porter, J. H., 1 Jan 2005, In : Drug Development Research. 64, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
13 Scopus citations

Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

Pehrson, A. L. & Moghaddam, B., 1 Sep 2010, In : Psychopharmacology. 211, 4, p. 443-455 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Impact of vortioxetine on synaptic integration in prefrontal-subcortical circuits: Comparisons with escitalopram

Chakroborty, S., Geisbush, T. R., Dale, E., Pehrson, A. L., Sánchez, C. & West, A. R., 26 Oct 2017, In : Frontiers in Pharmacology. 8, OCT, 764.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

In vivo and in vitro effects of vortioxetine on molecules associated with neuroplasticity

Kugathasan, P., Waller, J., Westrich, L., Abdourahman, A., Tamm, J. A., Pehrson, A. L., Dale, E., Gulinello, M., Sanchez, C. & Li, Y., 1 Mar 2017, In : Journal of Psychopharmacology. 31, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters-A rat microdialysis and electrophysiology study

Pehrson, A. L., Cremers, T., Bétry, C., van der Hart, M. G. C., Jørgensen, L., Madsen, M., Haddjeri, N., Ebert, B. & Sanchez, C., 1 Feb 2013, In : European Neuropsychopharmacology. 23, 2, p. 133-145 13 p.

Research output: Contribution to journalArticle

107 Scopus citations

Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - A quantitative EEG study in rats

Leiser, S. C., Pehrson, A. L., Robichaud, P. J. & Sanchez, C., 1 Jan 2014, In : British Journal of Pharmacology. 171, 18, p. 4255-4272 18 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Waller, J. A., Nygaard, S. H., Li, Y., Jardin, K. G., Tamm, J. A., Abdourahman, A., Elfving, B., Pehrson, A. L., Sánchez, C. & Wernersson, R., 4 Aug 2017, In : BMC Neuroscience. 18, 1, 56.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Pharmacological effects of Lu AA21004: A novel multimodal compound for the treatment of major depressive disorder

Mørk, A., Pehrson, A., Brennum, L. T., Møller Nielsen, S., Zhong, H., Lassen, A. B., Miller, S., Westrich, L., Boyle, N. J., Sánchez, C., Fischer, C. W., Liebenberg, N., Wegener, G., Bundgaard, C., Hogg, S., Bang-Andersen, B. & Bryan Stensbøl, T., 1 Mar 2012, In : Journal of Pharmacology and Experimental Therapeutics. 340, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

Open Access
205 Scopus citations

Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Li, Y., Abdourahman, A., Tamm, J. A., Pehrson, A. L., Sánchez, C. & Gulinello, M., 3 Jun 2015, In : Pharmacology Biochemistry and Behavior. 135, p. 70-82 13 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

Pehrson, A. L. & Sanchez, C., Apr 2014, In : CNS Spectrums. 19, 2, p. 121-133 13 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice

Philibin, S. D., Prus, A. J., Pehrson, A. L. & Porter, J. H., 1 Jun 2005, In : Psychopharmacology. 180, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse

Nackenoff, A. G., Simmler, L. D., Baganz, N. L., Pehrson, A. L., Sánchez, C. & Blakely, R. D., 17 May 2017, In : ACS Chemical Neuroscience. 8, 5, p. 1092-1100 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Task-and treatment length-dependent effects of vortioxetine on scopolamine-induced cognitive dysfunction and hippocampal extracellular acetylcholine in rats

Pehrson, A. L., Hillhouse, T. M., Haddjeri, N., Rovera, R., Porter, J. H., Mørk, A., Smagin, G., Song, D., Budac, D., Cajina, M. & Sanchez, C., Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 472-482 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: Enhancement of fluoxetine's effects by the α2 adrenoceptor antagonist yohimbine

Prus, A. J., Mooney-Leber, S. M., Berquist, M. D., Pehrson, A. L., Porter, N. P. & Porter, J. H., 8 Aug 2015, In : Behavioural Pharmacology. 26, 5, p. 489-494 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: Analysis of brain area epibatidine binding and cotinine levels

Pehrson, A. L., Philibin, S. D., Gross, D., Robinson, S. E., Vann, R. E., Rosecrans, J. A. & James, J. R., 1 May 2008, In : Pharmacology Biochemistry and Behavior. 89, 3, p. 424-431 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention

Pehrson, A. L., Bondi, C. O., Totah, N. K. B. & Moghaddam, B., 1 Jan 2013, In : Psychopharmacology. 225, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse

Jacobsen, J. P. R., Plenge, P., Sachs, B. D., Pehrson, A. L., Cajina, M., Du, Y., Roberts, W., Rudder, M. L., Dalvi, P., Robinson, T. J., O'Neill, S. P., Khoo, K. S., Morillo, C. S., Zhang, X. & Caron, M. G., Dec 2014, In : Psychopharmacology. 231, 23, p. 4527-4540 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT 3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

Dale, E., Grunnet, M., Pehrson, A. L., Frederiksen, K., Larsen, P. H., Nielsen, J., Stensbøl, T. B., Ebert, B., Yin, H., Lu, D., Liu, H., Jensen, T. N., Yang, C. R. & Sanchez, C., 15 Jun 2018, In : Brain Research. 1689, p. 1-11 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

Bétry, C., Pehrson, A. L., Etiévant, A., Ebert, B., Sánchez, C. & Haddjeri, N., 1 Jun 2013, In : International Journal of Neuropsychopharmacology. 16, 5, p. 1115-1127 13 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats

Prus, A. J., Pehrson, A. L., Philibin, S. D., Wood, J. T., Vunck, S. A. & Porter, J. H., 1 Apr 2009, In : Psychopharmacology. 203, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
Open Access
61 Scopus citations

Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

Jensen, J. B., du Jardin, K. G., Song, D., Budac, D., Smagin, G., Sanchez, C. & Pehrson, A. L., 1 Jan 2014, In : European Neuropsychopharmacology. 24, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Vortioxetine differentially modulates MK-801-induced changes in visual signal detection task performance and locomotor activity

Hillhouse, T. M., Merritt, C. R., Smith, D. A., Cajina, M., Sanchez, C., Porter, J. H. & Pehrson, A. L., 13 Sep 2018, In : Frontiers in Pharmacology. 9, SEP, 1024.

Research output: Contribution to journalArticle

Open Access
Open Access
92 Scopus citations

Vortioxetine improves context discrimination in mice through a neurogenesis independent mechanism

Felice, D., Guilloux, J. P., Pehrson, A., Li, Y., Mendez-David, I., Gardier, A. M., Sanchez, C. & David, D. J., 12 Mar 2018, In : Frontiers in Pharmacology. 9, MAR, 204.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Vortioxetine Reduces Marble Burying but only Transiently Enhances Social Interaction Preference in Adult Male BTBR T+Itpr3tf/J Mice

Witt, N. A., Lee, B., Ghent, K., Zhang, W. Q., Pehrson, A. L., Sánchez, C. & Gould, G. G., 16 Oct 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4319-4327 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

Wallace, A., Pehrson, A. L., Sánchez, C. & Morilak, D. A., Oct 2014, In : International Journal of Neuropsychopharmacology. 17, 10, p. 1695-1706 12 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations
Open Access
6 Scopus citations