Projects per year
Personal profile
University profile
Dr. Carlos A. Molina is a Professor of Molecular Biology at the College of Sciences and Mathematics of Montclair State University. Dr. Molina received his B.S. in Biology from the University of Puerto Rico, M.S. and Ph.D. in Biochemistry for Purdue University and postdoctoral training in molecular and cell biology at the University of Louis Pasteur in Strasbourg, France.
Using zebrafish as a model organism, Dr. Molina has focused his research in two areas, cancer and the female reproductive system. In the area of cancer research he seeks to understand the mechanisms involved in eliminating and misplacing a protein with tumor suppression activity in skin cancer cells. This data set the stage to test for pharmacological agents specifically targeted to inhibit the degradation and abnormal localization of this protein.
In the area of reproductive biology he is developing ovarian-specific transgenic zebrafish to dissect the molecular mechanisms of ovulation. These studies may lead to the development of new technologies in the field of agricultural livestock, where higher ovulation rates are desired. Further research in this area could also lead to the development of novel reproductive technologies.
Dr. Molina was the recipient several honors and grants from the American Association of Cancer Research, National Health Institute, National Science Foundation. He has been a member of the National Institutes of Health National Heart, Lung and Blood Institute and Department of Defense Ovarian and Prostate Cancer Study Sections.
Research interests
Research focus is in two areas, cancer and the female reproductive system. In the area of cancer research Dr. Molina seeks to understand the mechanisms involved in eliminating and misplacing a protein with tumor suppression activity in skin cancer cells. This data set the stage to test for pharmacological agents specifically targeted to inhibit the degradation and abnormal localization of this protein.
In the area of reproductive biology Dr. Molina is developing ovarian-specific transgenic zebrafish to dissect the molecular mechanisms of ovulation. These studies may lead to the development of new technologies in the field of agricultural livestock, where higher ovulation rates are desired. Further research in this area could also lead to the development of novel reproductive technologies.
Scholarly Interests
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 5 Finished
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IRES Track 1: US-Japan study of novel genetic elements regulating seasonal behavior of medaka fish.
Molina, C. (PI) & Munakata, M. (CoPI)
1/09/20 → 31/08/23
Project: Research
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Post-translational Regulation of Inducible cAMP Early Repressor and its Implications in Cancer
Molina, C. (PI)
National Institute of General Medical Sciences
1/05/18 → 30/04/22
Project: Research
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POST-TRANSLATIONAL REGULATION OF INDUCIBLE CAMP EARLY REPRESSOR AND ITS IMPLICATIONS IN CANCER
Molina, C. (PI)
National Institute of Health (NIH)
1/05/16 → 30/04/19
Project: Research
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Inducible cAMP Early Repressor in ovarian function.
Molina, C. (PI)
National Institute of Child Health and Human Development
16/12/03 → 30/11/05
Project: Research
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Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination
Cirinelli, A., Wheelan, J., Grieg, C. & Molina, C. A., 1 May 2022, In: Experimental Cell Research. 414, 1, 113083.Research output: Contribution to journal › Article › peer-review
Open Access -
Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells
Greco, S. J., Yehia, G., Potian, J. A., Molina, C. A. & Rameshwar, P., 1 Feb 2017, In: Stem Cell Reviews and Reports. 13, 1, p. 116-126 11 p.Research output: Contribution to journal › Article › peer-review
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The transcriptional repressor ICER binds to multiple loci throughout the genome
Muñiz, L. C. & Molina, C. A., 2016, In: Biochemical and Biophysical Research Communications. 478, 3, p. 1462-1465 4 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ras-induced melanoma transformation is associated with the proteasomal degradation of the transcriptional repressor ICER
Healey, M., Crow, M. S. & Molina, C. A., Sep 2013, In: Molecular Carcinogenesis. 52, 9, p. 692-704 13 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
P90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction
Le, N. T., Takei, Y., Shishido, T., Woo, C. H., Chang, E., Heo, K. S., Lee, H., Lu, Y., Morrell, C., Oikawa, M., McClain, C., Wang, X., Tournier, C., Molina, C. A., Taunton, J., Yan, C., Fujiwara, K., Patterson, C., Yang, J. & Abe, J. I., 17 Feb 2012, In: Circulation Research. 110, 4, p. 536-550 15 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations