Projects per year
Personal profile
University profile
Medicinal chemistry research in Dr. David Rotella's lab is a collaborative exercise where we engage other scientists with complimentary interests. Currently, they are engaged in discovery of protein kinase inhibitors for anti infective and anti inflammatory applications, in the discovery of new agents useful for the potential treatment of neurodegenerative diseases and enzyme inhibitors that can be used to treat botulism poisoning. Dr. Rotella is working with others at MSU as well as scientists in other universities and research institutes.
Research interests
Focused on drug discovery for CNS and neglected diseases.
Scholarly Interests
Medicinal chemistry. Drug discovery, hit to lead and lead optimization, medicinal chemistry, CNS, cardiovascular and metabolic disease expertise, intellectual property and expert witness.
Faculty/Media Expert
Expert on Medicinal chemistry, pharmaceuticals, and drug discovery.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Increasing Access to Graduate Degrees, Professional Development, and Research Experiences: Pathways to Achievement in Chemical Industries
Goodey, N. (PI), Schneemeyer, L. (CoPI), Siekierka, J. (CoPI), Rotella, D. (CoPI) & O'Neil, G. (CoPI)
1/01/21 → 31/12/25
Project: Research
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MRI: Acquisition of a High-Resolution Accurate-Mass Orbitrap LC-MS System at Montclair State University
Gao, J. (PI), Wu, M. S. (CoPI), Goodey, N. (CoPI), Deng, Y. (CoPI) & Rotella, D. (CoPI)
1/08/21 → 31/07/24
Project: Research
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Pharmacologic Inhibition of PDE11A for Age-Related Memory Disorders
Rotella, D. (PI), Hoffman, C. S. (CoPI) & Kelly, M. (CoPI)
15/09/20 → 30/04/25
Project: Research
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Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemoprevention
Bhanot, P. (PI), Rotella, D. (CoPI) & Siekierka, J. (CoPI)
National Institute of Allergy and Infectious Diseases
1/08/17 → 31/07/21
Project: Research
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First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders
Mahmood, S. U., Eberhard, J., Hoffman, C. S., Colussi, D., Gordon, J., Childers, W., Amurrio, E., Patel, J., Kelly, M. P. & Rotella, D. P., 10 Oct 2024, In: Journal of Medicinal Chemistry. 67, 19, p. 17774-17784 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
Gilleran, J. A., Ashraf, K., Delvillar, M., Eck, T., Fondekar, R., Miller, E. B., Hutchinson, A., Dong, A., Seitova, A., De Souza, M. L., Augeri, D., Halabelian, L., Siekierka, J., Rotella, D. P., Gordon, J., Childers, W. E., Grier, M. C., Staker, B. L., Roberge, J. Y. & Bhanot, P., 14 Mar 2024, In: Journal of Medicinal Chemistry. 67, 5, p. 3467-3503 37 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline
Mahmood, S. U., Lozano Gonzalez, M., Tummalapalli, S., Eberhard, J., Ly, J., Hoffman, C. S., Kelly, M. P., Gordon, J., Colussi, D., Childers, W. & Rotella, D. P., 9 Nov 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14597-14608 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Patrick M. Woster Memorial Commentary
Rotella, D. P. & Georg, G., 12 Oct 2023, In: ACS Medicinal Chemistry Letters. 14, 10, p. 1305-1309 5 p.Research output: Contribution to journal › Editorial
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Patrick M. Woster Memorial Commentary
Rotella, D. P. & Georg, G., 2023, (Accepted/In press) In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Editorial
Prizes
Press/Media
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HOT SUMMER DAYS IGNITE SCIENTIFIC MINDS
Rotella, D., Cui, Y., Bologna, P., Keenan, J., Billings, L. & Vega, Q.
17/07/23
1 item of Media coverage
Press/Media
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Hot Summer Days Ignite Scientific Minds
Rotella, D., Cui, Y., Bologna, P., Keenan, J., Kight, S., Billings, L., Li, R. & Vega, Q.
17/07/23
1 item of Media coverage
Press/Media
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Montclair State Professor Shares Cancer Remission Journey
Rotella, D., Herbert, K. & Whitener, M.
15/02/23
1 item of Media coverage
Press/Media
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Professor Shares Cancer Remission Journey
Rotella, D., Herbert, K. & Whitener, M.
13/02/23
1 item of Media coverage
Press/Media
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PROFESSOR SHARES CANCER REMISSION JOURNEY
Rotella, D., Herbert, K. & Whitener, M.
13/02/23
1 item of Media coverage
Press/Media