• 1207 Citations
  • 18 h-Index
1987 …2018
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Research Output 1987 2018

2018
1 Citation (Scopus)

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. & Rotella, D., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

Filarial Elephantiasis
Structure-Activity Relationship
Protein Kinase Inhibitors
Heat-Shock Proteins
Protein Kinases
1 Citation (Scopus)

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Tobias, A. M., Toska, D., Lange, K., Eck, T., Bhat, R., Janson, C. A., Rotella, D. P., Gubler, U. & Goodey, N. M., May 2018, In : PLoS ONE. 13, 5, e0197173.

Research output: Contribution to journalArticle

Wuchereria bancrofti
Aminopterin
dihydrofolate reductase
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
2017
1 Citation (Scopus)

Comprehensive Medicinal Chemistry III

Chackalamannil, S., Rotella, D. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. 1-4369 4369 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biological Products
Medicine
Bispecific Antibodies
Peptide Nucleic Acids
Molecules
4 Citations (Scopus)

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds

Minnow, Y. V. T., Goldberg, R., Tummalapalli, S. R., Rotella, D. P. & Goodey, N. M., 15 Mar 2017, In : Archives of Biochemistry and Biophysics. 618, p. 15-22 8 p.

Research output: Contribution to journalArticle

Hydroxyquinolines
Type A Botulinum Toxins
Light
Tetanus Toxin
Structure-Activity Relationship

Preface

Chackalamannil, S., Rotella, D. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. v-vi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Synthesis and computational analysis of conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines

Tummalapalli, S. R., Bhat, R., Waitt, C., Eshuis, H. & Rotella, D. P., 1 Jan 2017, In : Tetrahedron Letters. 58, 43, p. 4087-4089 3 p.

Research output: Contribution to journalArticle

Organic Chemistry
Diamines
Pharmaceutical Chemistry
Scaffolds
Computer Simulation
2016
3 Citations (Scopus)

The Critical Role of Organic Chemistry in Drug Discovery

Rotella, D., 19 Oct 2016, In : ACS Chemical Neuroscience. 7, 10, p. 1315-1316 2 p.

Research output: Contribution to journalShort survey

Organic Chemistry
Drug Discovery
Industry
Personnel
Molecules
2015

Preface

Fischer, J. & Rotella, D., 30 Jan 2015, Successful Drug Discovery. wiley, p. XIII-XV

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

1 Citation (Scopus)

Serendipitous target-based drug discoveries

Fischer, J. & Rotella, D., 30 Jan 2015, Successful Drug Discovery. wiley, p. 3-18 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Citalopram
Omeprazole
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
1 Citation (Scopus)

Successful drug discovery

Fischer, J. & Rotella, D. P., 30 Jan 2015, wiley. 235 p.

Research output: Book/ReportBook

Drug Discovery
Pharmaceutical Preparations
Reference Books
Inventors
Pharmaceutical Chemistry
2014
74 Citations (Scopus)

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Bhat, R., Tummalapalli, S. R. & Rotella, D. P., 13 Nov 2014, In : Journal of Medicinal Chemistry. 57, 21, p. 8718-8728 11 p.

Research output: Contribution to journalReview article

HSP90 Heat-Shock Proteins
Protein Isoforms
Clinical Trials
Research
Proteins

Recent Results In Phosphodiesterase Inhibitor Development and CNS Applications

Rotella, D., 28 Apr 2014, Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. Wiley Blackwell, p. 115-144 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Erectile Dysfunction
Nervous System Diseases
Psychiatry
9 Citations (Scopus)

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Deloison, G., Rouillé, Y., Séron, K. & Rotella, D. P., 1 Sep 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4162-4165 4 p.

Research output: Contribution to journalArticle

Virus Internalization
Viruses
Hepacivirus
Derivatives
Pharmaceutical Preparations
8 Citations (Scopus)

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Gasiewicz, T. A., Henry, E. C. & Rotella, D. P., 15 May 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 10, p. 2263-2266 4 p.

Research output: Contribution to journalArticle

Drug Discovery
Esters
Pharmaceutical Preparations
Hydroxyl Radical
Stereochemistry
2013
8 Citations (Scopus)

The discovery and development of boceprevir

Rotella, D. P., 1 Nov 2013, In : Expert Opinion on Drug Discovery. 8, 11, p. 1439-1447 9 p.

Research output: Contribution to journalReview article

Peptide Hydrolases
Peptidomimetics
Therapeutics
Ribavirin
Expert Testimony
13 Citations (Scopus)

The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: Dependence on solvent polarity

Snitsarev, V., Young, M. N., Miller, R. M. S. & Rotella, D. P., 22 Nov 2013, In : PLoS ONE. 8, 11, e79834.

Research output: Contribution to journalArticle

epigallocatechin
Fluorescence
fluorescence
dimethyl sulfoxide
Dimethyl Sulfoxide
2012
8 Citations (Scopus)

Analogue-Based Drug Discovery III

Fischer, J., Ganellin, C. R. & Rotella, D., 18 Dec 2012, Wiley-VCH.

Research output: Book/ReportBook

Drug Discovery
Pharmaceutical Preparations
Inventors
Pharmaceutical Chemistry
Research Personnel
5 Citations (Scopus)

Drug discovery 2012 and beyond

Rotella, D., 8 Mar 2012, In : ACS Medicinal Chemistry Letters. 3, 3, p. 172-173 2 p.

Research output: Contribution to journalComment/debate

Drug Discovery

Pioneer and Analogue Drugs

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. 1-19 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Direct analogs
Dipeptidyl-Peptidase IV Inhibitors
Histamine H2 Antagonists
Serotonin Uptake Inhibitors
Angiotensin-Converting Enzyme Inhibitors

Preface

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. xiii-xiv

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

15 Citations (Scopus)

Recent results in protein kinase inhibition for tropical diseases

Rotella, D., 15 Nov 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 22, p. 6788-6793 6 p.

Research output: Contribution to journalReview article

Protein Kinases
Parasitic Diseases
Leishmaniasis
Enzyme Inhibitors
Malaria
1 Citation (Scopus)

Welcome to pharmaceutical patent analyst

Jones, L. H., Rotella, D. & Doca, G., 1 Jan 2012, In : Pharmaceutical Patent Analyst. 1, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Research Peer Review
Delivery of Health Care
Pharmaceutical Preparations
2010
12 Citations (Scopus)

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Yan, Y., Zhou, P., Rotella, D. P., Feenstra, R., Kruse, C. G., Reinders, J. H., Neut, M. V. D., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Marquis, K. L., Pausch, M. H. & Robichaud, A. J., 1 May 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 9, p. 2983-2986 4 p.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Dopamine
Schizophrenia
Amines
Ligands

Selective Serotonin Reuptake Inhibitors for the Treatment of Depression

Childers, W. E. & Rotella, D., 30 Aug 2010, Analogue-Based Drug Discovery II. Wiley-VCH, p. 269-295 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Norepinephrine Plasma Membrane Transport Proteins
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
12 Citations (Scopus)

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol- 2(3H)-one]: A novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

Brennan, J. A., Graf, R., Grauer, S. M., Navarra, R. L., Pulicicchio, C. M., Hughes, Z. A., Lin, Q., Wantuch, C., Rosenzweig-Lipson, S., Pruthi, F., Lai, M., Smith, D., Goutier, W., Van De Neut, M., Robichaud, A. J., Rotella, D., Feenstra, R. W., Kruse, C., Broqua, P., Beyer, C. E. & 3 others, McCreary, A. C., Pausch, M. H. & Marquis, K. L., 1 Jan 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Serotonin Uptake Inhibitors
Antidepressive Agents
Antipsychotic Agents
Serotonin Plasma Membrane Transport Proteins
2009
1 Citation (Scopus)

Alzheimer's disease: A light at the end of the tunnel?

Robichaud, A. J. & Rotella, D., 1 Mar 2009, In : Drug Development Research. 70, 2, p. 57-59 3 p.

Research output: Contribution to journalEditorial

Alzheimer Disease

American chemical society - 238th national meeting & exposition. Novel small molecule therapeutics

Rotella, D., 1 Oct 2009, In : IDrugs. 12, 10, p. 612-613 2 p.

Research output: Contribution to journalArticle

Purinergic P1 Receptor Agonists
PAR-2 Receptor
Purinergic P1 Receptor Antagonists
Anti-Inflammatory Agents
Therapeutics
14 Citations (Scopus)

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Rotella, D. P., McFarlane, G. R., Greenfield, A., Grosanu, C., Robichaud, A. J., Denny, R. A., Feenstra, R. W., Núñez-García, S., Reinders, J. H., Neut, M. V. D., McCreary, A., Kruse, C. G., Sullivan, K., Pruthi, F., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Grauer, S. M., Navarra, R. L. & 4 others, Graf, R., Brennan, J., Marquis, K. L. & Pausch, M. H., 1 Oct 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5552-5555 4 p.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Dopamine
Schizophrenia
Dopamine D2 Receptors
Assays
2008

American Chemical Society - 235th national meeting: Part 3

Rotella, D., 1 Jun 2008, In : IDrugs. 11, 6, p. 394-396 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
Antidiarrheals
Cystic Fibrosis Transmembrane Conductance Regulator
Urokinase-Type Plasminogen Activator
Drug Industry

American Chemical Society - 236th National Meeting & Exposition. Drug development for tuberculosis and cancer

Rotella, D., 1 Oct 2008, In : IDrugs. 11, 10, p. 699-701 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-met
Vinca Alkaloids
Antitubercular Agents
Kinesin
Preclinical Drug Evaluations

American Chemical Society - 236th National Meeting & Exposition. New Frontiers in Drug Delivery

Rotella, D., 1 Oct 2008, In : IDrugs. 11, 10, p. 702-704 3 p.

Research output: Contribution to journalArticle

Peritoneal Diseases
Drug-Eluting Stents
Eye Diseases
Drug Delivery Systems
RNA Interference

Medicinal Chemistry - XXth International Symposium. Lead finding strategies and kinase selectivity

Rotella, D., 1 Nov 2008, In : IDrugs. 11, 11, p. 774-778 5 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Pharmaceutical Chemistry
Drug Design
Enzyme Inhibitors
Antineoplastic Agents

Medicinal Chemistry - XXth International Symposium. Natural products and neurodegenerative diseases

Rotella, D., 1 Nov 2008, In : IDrugs. 11, 11, p. 779-782 4 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Pharmaceutical Chemistry
Enzyme Inhibitors
Medicinal Plants
Biological Products
2007

American Chemical Society - 233rd national meeting. CNS, cancer and cardiovascular targets

Rotella, D., 1 May 2007, In : IDrugs. 10, 5, p. 310-312 3 p.

Research output: Contribution to journalArticle

CD18 Antigens
CD11b Antigens
Piperazines
Lobeline
Vesicular Monoamine Transport Proteins

American Chemical Society - 234th National meeting - Syntheses of novel compounds and data on novel therapeutics

Rotella, D., 1 Oct 2007, In : IDrugs. 10, 10, p. 681-685 5 p.

Research output: Contribution to journalArticle

Adrenergic Uptake Inhibitors
Janus Kinase 3
HSP90 Heat-Shock Proteins
Thiazoles
PPAR alpha
16 Citations (Scopus)

Chapter 1 Potential CNS Applications for Phosphodiesterase Enzyme Inhibitors

Brandon, N. J. & Rotella, D. P., 15 Nov 2007, Annual Reports in Medicinal Chemistry. Macor, J. (ed.). p. 3-12 10 p. (Annual Reports in Medicinal Chemistry; vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Enzyme Inhibitors
Enzymes
Availability
23 Citations (Scopus)

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Simpkins, L. M., Bolton, S., Pi, Z., Sutton, J. C., Kwon, C., Zhao, G., Magnin, D. R., Augeri, D. J., Gungor, T., Rotella, D. P., Sun, Z., Liu, Y., Slusarchyk, W. S., Marcinkeviciene, J., Robertson, J. G., Wang, A., Robl, J. A., Atwal, K. S., Zahler, R. L., Parker, R. A. & 2 others, Kirby, M. S. & Hamann, L. G., 1 Dec 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 23, p. 6476-6480 5 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Structure-Activity Relationship
Scaffolds
Nitrogen
Amino Acids
2006
Biological Models
PPAR gamma
Opioid Receptors
G-Protein-Coupled Receptors
Gene Library
Pharmaceutical Chemistry
1 Citation (Scopus)
Aspartic Acid Endopeptidases
Endopeptidases
Amyloid Precursor Protein Secretases
Preclinical Drug Evaluations
Enzyme Inhibitors

American chemical society 232nd national meeting. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 745-747 3 p.

Research output: Contribution to journalArticle

Aminoquinolines
Potassium Channel Blockers
Benzimidazoles
Investigational Drugs
MAP Kinase Kinase Kinases
1 Citation (Scopus)

COMP-Structure-Based Design and Development of Estrogen Receptor Modulators. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 748-750 3 p.

Research output: Contribution to journalArticle

Oxazoles
Investigational Drugs
Selective Estrogen Receptor Modulators
Estrogen Receptor beta
Molecular Models
4 Citations (Scopus)

Phosphodiesterases

Rotella, D. P., 1 Nov 2006, Comprehensive Medicinal Chemistry II. Elsevier Ltd., Vol. 2. p. 919-957 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphoric Diester Hydrolases
2005

American Chemical Society - 229th National Meeting. Bench to pilot plant: 13-17 March 2005, San Diego, CA, USA

Rotella, D., 1 May 2005, In : IDrugs. 8, 5, p. 390-391 2 p.

Research output: Contribution to journalArticle

3',5'-Cyclic-AMP Phosphodiesterases
Pharmaceutical Technology
Phosphodiesterase Inhibitors
Pharmaceutical Chemistry
Chronic Obstructive Pulmonary Disease

American Chemical Society - 229th National Meeting. Carbohydrate vaccines: 13-17 March 2005, San Diego, CA, USA

Rotella, D., 1 May 2005, In : IDrugs. 8, 5, p. 387-389 3 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Cancer Vaccines
Synthetic Vaccines
Vaccines
Carbohydrates

American Chemical Society - 230th National Meeting Medicinal chemistry. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D., 1 Nov 2005, In : IDrugs. 8, 11, p. 871-875 5 p.

Research output: Contribution to journalArticle

Viral Nonstructural Proteins
Prostaglandin E Receptors
Protein Tyrosine Phosphatases
Pharmaceutical Chemistry
Drug Design
42 Citations (Scopus)

Discovery and structure-activity relationships of 2-benzylpyrrolidine- substituted aryloxypropanols as calcium-sensing receptor antagonists

Yang, W., Wang, Y., Roberge, J. Y., Ma, Z., Liu, Y., Lawrence, R. M., Rotella, D., Seethala, R., Feyen, J. H. M. & Dickson, J. K., 15 Feb 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1225-1228 4 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Structure-Activity Relationship
Ether
Amines
Genes

Proteins, peptides, amino acids and enzyme inhibitors. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D., 1 Nov 2005, In : IDrugs. 8, 11, p. 878-879 2 p.

Research output: Contribution to journalArticle

Amino Acids, Peptides, and Proteins
Depsipeptides
Protein Folding
Enzyme Inhibitors
Amino Acids

Technical achievements in organic chemistry. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D., 1 Nov 2005, In : IDrugs. 8, 11, p. 876-877 2 p.

Research output: Contribution to journalArticle

Integrin alphaVbeta3
Organic Chemistry
HIV Protease Inhibitors
Enzyme Inhibitors
Caspases
2004
Molecular Mimicry
Phosphotyrosine
Hydrogels
Hypoglycemic Agents
Blood Glucose