• 1237 Citations
  • 18 h-Index
1987 …2018

Research output per year

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Research Output

2018

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. J. & Rotella, D. P., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Tobias, A. M., Toska, D., Lange, K., Eck, T., Bhat, R., Janson, C. A., Rotella, D. P., Gubler, U. & Goodey, N. M., May 2018, In : PLoS ONE. 13, 5, e0197173.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Comprehensive Medicinal Chemistry III

Chackalamannil, S., Rotella, D. P. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. 1-4369 4369 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds

Minnow, Y. V. T., Goldberg, R., Tummalapalli, S. R., Rotella, D. P. & Goodey, N. M., 15 Mar 2017, In : Archives of Biochemistry and Biophysics. 618, p. 15-22 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Preface

Chackalamannil, S., Rotella, D. P. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. v-vi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Synthesis and computational analysis of conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines

Tummalapalli, S. R., Bhat, R., Waitt, C., Eshuis, H. & Rotella, D. P., 1 Jan 2017, In : Tetrahedron Letters. 58, 43, p. 4087-4089 3 p.

Research output: Contribution to journalArticle

2016

The Critical Role of Organic Chemistry in Drug Discovery

Rotella, D. P., 19 Oct 2016, In : ACS Chemical Neuroscience. 7, 10, p. 1315-1316 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations
2015

Preface

Fischer, J. & Rotella, D. P., 30 Jan 2015, Successful Drug Discovery. wiley, p. XIII-XV

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Serendipitous target-based drug discoveries

Fischer, J. & Rotella, D. P., 30 Jan 2015, Successful Drug Discovery. wiley, p. 3-18 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Successful drug discovery

Fischer, J. & Rotella, D. P., 30 Jan 2015, wiley. 235 p.

Research output: Book/ReportBook

1 Scopus citations
2014

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Bhat, R., Tummalapalli, S. R. & Rotella, D. P., 13 Nov 2014, In : Journal of Medicinal Chemistry. 57, 21, p. 8718-8728 11 p.

Research output: Contribution to journalReview article

83 Scopus citations

Recent Results In Phosphodiesterase Inhibitor Development and CNS Applications

Rotella, D. P., 28 Apr 2014, Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. Wiley Blackwell, p. 115-144 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Deloison, G., Rouillé, Y., Séron, K. & Rotella, D. P., 1 Sep 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4162-4165 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Gasiewicz, T. A., Henry, E. C. & Rotella, D. P., 15 May 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 10, p. 2263-2266 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

The discovery and development of boceprevir

Rotella, D. P., 1 Nov 2013, In : Expert Opinion on Drug Discovery. 8, 11, p. 1439-1447 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: Dependence on solvent polarity

Snitsarev, V., Young, M. N., Miller, R. M. S. & Rotella, D. P., 22 Nov 2013, In : PLoS ONE. 8, 11, e79834.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Analogue-Based Drug Discovery III

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Wiley-VCH.

Research output: Book/ReportBook

8 Scopus citations

Drug discovery 2012 and beyond

Rotella, D. P., 8 Mar 2012, In : ACS Medicinal Chemistry Letters. 3, 3, p. 172-173 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Pioneer and Analogue Drugs

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. 1-19 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Preface

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. xiii-xiv

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Recent results in protein kinase inhibition for tropical diseases

Rotella, D. P., 15 Nov 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 22, p. 6788-6793 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Welcome to pharmaceutical patent analyst

Jones, L. H., Rotella, D. P. & Doca, G., 1 Jan 2012, In : Pharmaceutical Patent Analyst. 1, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2010

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Yan, Y., Zhou, P., Rotella, D. P., Feenstra, R., Kruse, C. G., Reinders, J. H., Neut, M. V. D., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Marquis, K. L., Pausch, M. H. & Robichaud, A. J., 1 May 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 9, p. 2983-2986 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Selective Serotonin Reuptake Inhibitors for the Treatment of Depression

Childers, W. E. & Rotella, D. P., 30 Aug 2010, Analogue-Based Drug Discovery II. Wiley-VCH, p. 269-295 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol- 2(3H)-one]: A novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

Brennan, J. A., Graf, R., Grauer, S. M., Navarra, R. L., Pulicicchio, C. M., Hughes, Z. A., Lin, Q., Wantuch, C., Rosenzweig-Lipson, S., Pruthi, F., Lai, M., Smith, D., Goutier, W., Van De Neut, M., Robichaud, A. J., Rotella, D., Feenstra, R. W., Kruse, C., Broqua, P., Beyer, C. E. & 3 others, McCreary, A. C., Pausch, M. H. & Marquis, K. L., 1 Jan 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009

Alzheimer's disease: A light at the end of the tunnel?

Robichaud, A. J. & Rotella, D. P., 1 Mar 2009, In : Drug Development Research. 70, 2, p. 57-59 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

American chemical society - 238th national meeting & exposition. Novel small molecule therapeutics

Rotella, D. P., 1 Oct 2009, In : IDrugs. 12, 10, p. 612-613 2 p.

Research output: Contribution to journalArticle

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Rotella, D. P., McFarlane, G. R., Greenfield, A., Grosanu, C., Robichaud, A. J., Denny, R. A., Feenstra, R. W., Núñez-García, S., Reinders, J. H., Neut, M. V. D., McCreary, A., Kruse, C. G., Sullivan, K., Pruthi, F., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Grauer, S. M., Navarra, R. L. & 4 others, Graf, R., Brennan, J., Marquis, K. L. & Pausch, M. H., 1 Oct 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5552-5555 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

American Chemical Society - 235th national meeting: Part 3

Rotella, D., 1 Jun 2008, In : IDrugs. 11, 6, p. 394-396 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 236th National Meeting & Exposition. Drug development for tuberculosis and cancer

Rotella, D. P., 1 Oct 2008, In : IDrugs. 11, 10, p. 699-701 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 236th National Meeting & Exposition. New Frontiers in Drug Delivery

Rotella, D. P., 1 Oct 2008, In : IDrugs. 11, 10, p. 702-704 3 p.

Research output: Contribution to journalArticle

Medicinal Chemistry - XXth International Symposium. Lead finding strategies and kinase selectivity

Rotella, D. P., 1 Nov 2008, In : IDrugs. 11, 11, p. 774-778 5 p.

Research output: Contribution to journalArticle

Medicinal Chemistry - XXth International Symposium. Natural products and neurodegenerative diseases

Rotella, D. P., 1 Nov 2008, In : IDrugs. 11, 11, p. 779-782 4 p.

Research output: Contribution to journalArticle

2007

American Chemical Society - 233rd national meeting. CNS, cancer and cardiovascular targets

Rotella, D., 1 May 2007, In : IDrugs. 10, 5, p. 310-312 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 234th National meeting - Syntheses of novel compounds and data on novel therapeutics

Rotella, D., 1 Oct 2007, In : IDrugs. 10, 10, p. 681-685 5 p.

Research output: Contribution to journalArticle

Chapter 1 Potential CNS Applications for Phosphodiesterase Enzyme Inhibitors

Brandon, N. J. & Rotella, D. P., 15 Nov 2007, Annual Reports in Medicinal Chemistry. Macor, J. (ed.). p. 3-12 10 p. (Annual Reports in Medicinal Chemistry; vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Simpkins, L. M., Bolton, S., Pi, Z., Sutton, J. C., Kwon, C., Zhao, G., Magnin, D. R., Augeri, D. J., Gungor, T., Rotella, D. P., Sun, Z., Liu, Y., Slusarchyk, W. S., Marcinkeviciene, J., Robertson, J. G., Wang, A., Robl, J. A., Atwal, K. S., Zahler, R. L., Parker, R. A. & 2 others, Kirby, M. S. & Hamann, L. G., 1 Dec 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 23, p. 6476-6480 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

American chemical society 232nd national meeting. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 745-747 3 p.

Research output: Contribution to journalArticle

COMP-Structure-Based Design and Development of Estrogen Receptor Modulators. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 748-750 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Phosphodiesterases

Rotella, D. P., 1 Nov 2006, Comprehensive Medicinal Chemistry II. Elsevier Ltd., Vol. 2. p. 919-957 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2005

American Chemical Society - 229th National Meeting. Bench to pilot plant: 13-17 March 2005, San Diego, CA, USA

Rotella, D. P., 1 May 2005, In : IDrugs. 8, 5, p. 390-391 2 p.

Research output: Contribution to journalArticle

American Chemical Society - 229th National Meeting. Carbohydrate vaccines: 13-17 March 2005, San Diego, CA, USA

Rotella, D. P., 1 May 2005, In : IDrugs. 8, 5, p. 387-389 3 p.

Research output: Contribution to journalArticle

Discovery and structure-activity relationships of 2-benzylpyrrolidine- substituted aryloxypropanols as calcium-sensing receptor antagonists

Yang, W., Wang, Y., Roberge, J. Y., Ma, Z., Liu, Y., Lawrence, R. M., Rotella, D. P., Seethala, R., Feyen, J. H. M. & Dickson, J. K., 15 Feb 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1225-1228 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Proteins, peptides, amino acids and enzyme inhibitors. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D. P., 1 Nov 2005, In : IDrugs. 8, 11, p. 878-879 2 p.

Research output: Contribution to journalArticle

Technical achievements in organic chemistry. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D. P., 1 Nov 2005, In : IDrugs. 8, 11, p. 876-877 2 p.

Research output: Contribution to journalArticle