• 1248 Citations
  • 18 h-Index
1987 …2018

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2018

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. J. & Rotella, D. P., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Tobias, A. M., Toska, D., Lange, K., Eck, T., Bhat, R., Janson, C. A., Rotella, D. P., Gubler, U. & Goodey, N. M., May 2018, In : PLoS ONE. 13, 5, e0197173.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds

Minnow, Y. V. T., Goldberg, R., Tummalapalli, S. R., Rotella, D. P. & Goodey, N. M., 15 Mar 2017, In : Archives of Biochemistry and Biophysics. 618, p. 15-22 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and computational analysis of conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines

Tummalapalli, S. R., Bhat, R., Waitt, C., Eshuis, H. & Rotella, D. P., 1 Jan 2017, In : Tetrahedron Letters. 58, 43, p. 4087-4089 3 p.

Research output: Contribution to journalArticle

2014

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Deloison, G., Rouillé, Y., Séron, K. & Rotella, D. P., 1 Sep 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4162-4165 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Gasiewicz, T. A., Henry, E. C. & Rotella, D. P., 15 May 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 10, p. 2263-2266 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: Dependence on solvent polarity

Snitsarev, V., Young, M. N., Miller, R. M. S. & Rotella, D. P., 22 Nov 2013, In : PLoS ONE. 8, 11, e79834.

Research output: Contribution to journalArticle

15 Scopus citations
2010

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Yan, Y., Zhou, P., Rotella, D. P., Feenstra, R., Kruse, C. G., Reinders, J. H., Neut, M. V. D., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Marquis, K. L., Pausch, M. H. & Robichaud, A. J., 1 May 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 9, p. 2983-2986 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol- 2(3H)-one]: A novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

Brennan, J. A., Graf, R., Grauer, S. M., Navarra, R. L., Pulicicchio, C. M., Hughes, Z. A., Lin, Q., Wantuch, C., Rosenzweig-Lipson, S., Pruthi, F., Lai, M., Smith, D., Goutier, W., Van De Neut, M., Robichaud, A. J., Rotella, D., Feenstra, R. W., Kruse, C., Broqua, P., Beyer, C. E. & 3 others, McCreary, A. C., Pausch, M. H. & Marquis, K. L., 1 Jan 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009

American chemical society - 238th national meeting & exposition. Novel small molecule therapeutics

Rotella, D. P., 1 Oct 2009, In : IDrugs. 12, 10, p. 612-613 2 p.

Research output: Contribution to journalArticle

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Rotella, D. P., McFarlane, G. R., Greenfield, A., Grosanu, C., Robichaud, A. J., Denny, R. A., Feenstra, R. W., Núñez-García, S., Reinders, J. H., Neut, M. V. D., McCreary, A., Kruse, C. G., Sullivan, K., Pruthi, F., Lai, M., Zhang, J., Kowal, D. M., Carrick, T., Grauer, S. M., Navarra, R. L. & 4 others, Graf, R., Brennan, J., Marquis, K. L. & Pausch, M. H., 1 Oct 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5552-5555 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

American Chemical Society - 235th national meeting: Part 3

Rotella, D., 1 Jun 2008, In : IDrugs. 11, 6, p. 394-396 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 236th National Meeting & Exposition. Drug development for tuberculosis and cancer

Rotella, D. P., 1 Oct 2008, In : IDrugs. 11, 10, p. 699-701 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 236th National Meeting & Exposition. New Frontiers in Drug Delivery

Rotella, D. P., 1 Oct 2008, In : IDrugs. 11, 10, p. 702-704 3 p.

Research output: Contribution to journalArticle

Medicinal Chemistry - XXth International Symposium. Lead finding strategies and kinase selectivity

Rotella, D. P., 1 Nov 2008, In : IDrugs. 11, 11, p. 774-778 5 p.

Research output: Contribution to journalArticle

Medicinal Chemistry - XXth International Symposium. Natural products and neurodegenerative diseases

Rotella, D. P., 1 Nov 2008, In : IDrugs. 11, 11, p. 779-782 4 p.

Research output: Contribution to journalArticle

2007

American Chemical Society - 233rd national meeting. CNS, cancer and cardiovascular targets

Rotella, D., 1 May 2007, In : IDrugs. 10, 5, p. 310-312 3 p.

Research output: Contribution to journalArticle

American Chemical Society - 234th National meeting - Syntheses of novel compounds and data on novel therapeutics

Rotella, D., 1 Oct 2007, In : IDrugs. 10, 10, p. 681-685 5 p.

Research output: Contribution to journalArticle

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Simpkins, L. M., Bolton, S., Pi, Z., Sutton, J. C., Kwon, C., Zhao, G., Magnin, D. R., Augeri, D. J., Gungor, T., Rotella, D. P., Sun, Z., Liu, Y., Slusarchyk, W. S., Marcinkeviciene, J., Robertson, J. G., Wang, A., Robl, J. A., Atwal, K. S., Zahler, R. L., Parker, R. A. & 2 others, Kirby, M. S. & Hamann, L. G., 1 Dec 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 23, p. 6476-6480 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

American chemical society 232nd national meeting. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 745-747 3 p.

Research output: Contribution to journalArticle

COMP-Structure-Based Design and Development of Estrogen Receptor Modulators. 10-14 September 2006, San Francisco, CA, USA

Rotella, D., 1 Nov 2006, In : IDrugs. 9, 11, p. 748-750 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2005

American Chemical Society - 229th National Meeting. Bench to pilot plant: 13-17 March 2005, San Diego, CA, USA

Rotella, D. P., 1 May 2005, In : IDrugs. 8, 5, p. 390-391 2 p.

Research output: Contribution to journalArticle

American Chemical Society - 229th National Meeting. Carbohydrate vaccines: 13-17 March 2005, San Diego, CA, USA

Rotella, D. P., 1 May 2005, In : IDrugs. 8, 5, p. 387-389 3 p.

Research output: Contribution to journalArticle

Discovery and structure-activity relationships of 2-benzylpyrrolidine- substituted aryloxypropanols as calcium-sensing receptor antagonists

Yang, W., Wang, Y., Roberge, J. Y., Ma, Z., Liu, Y., Lawrence, R. M., Rotella, D. P., Seethala, R., Feyen, J. H. M. & Dickson, J. K., 15 Feb 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1225-1228 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Proteins, peptides, amino acids and enzyme inhibitors. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D. P., 1 Nov 2005, In : IDrugs. 8, 11, p. 878-879 2 p.

Research output: Contribution to journalArticle

Technical achievements in organic chemistry. 28 August - 1 September 2005, Washington, DC, USA

Rotella, D. P., 1 Nov 2005, In : IDrugs. 8, 11, p. 876-877 2 p.

Research output: Contribution to journalArticle

American Chemical Society - 228th National meeting. Technical achievements in organic synthesis

Rotella, D. P., 1 Oct 2004, In : IDrugs. 7, 10, p. 889-892 4 p.

Research output: Contribution to journalArticle

Wolfrom/Isbell New Investigator Award Symposium

Rotella, D. P., 1 Oct 2004, In : IDrugs. 7, 10, p. 893-894 2 p.

Research output: Contribution to journalArticle

2002

American Chemical Society - 223rd National Meeting: New Clinical Candidates: 7-11 April 2002, Orlando, FL, USA

Rotella, D., 1 Dec 2002, In : IDrugs. 5, 5, p. 430-432 3 p.

Research output: Contribution to journalArticle

2000

A cholesterol ester transfer protein inhibitor attenuates atherosclerosis in rabbits

Rotella, D. P., 22 Nov 2000, In : Chemtracts. 13, 9, p. 630-632 3 p.

Research output: Contribution to journalArticle

N-3-substituted imidazoquinazolinones: Potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

Rotella, D. P., Sun, Z., Zhu, Y., Krupinski, J., Pongrac, R., Seliger, L., Normandin, D. & Macor, J. E., 6 Apr 2000, In : Journal of Medicinal Chemistry. 43, 7, p. 1257-1263 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors

Rotella, D. P., Sun, Z., Zhu, Y., Krupinski, J., Pongrac, R., Seliger, L., Normandin, D. & Macor, J. E., 28 Dec 2000, In : Journal of Medicinal Chemistry. 43, 26, p. 5037-5043 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
1999

Rank-order of potencies for inhibition of the secretion of Aβ40 and Aβ42 suggests that both are generated by a single γ-secretase

Durkin, J. T., Murthy, S., Husten, E. J., Trusko, S. P., Savage, M. J., Rotella, D. P., Greenberg, B. D. & Siman, R., 16 Jul 1999, In : Journal of Biological Chemistry. 274, 29, p. 20499-20504 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
1998

Novel biologically active nonpeptidic inhibitors of myristoyl-CoA:protein N-myristoyltransferase

Rotella, D. P., 1 Aug 1998, In : Chemtracts. 11, 9, p. 667-670 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
1997

Antibacterial agents that inhibit lipid A biosynthesis

Rotella, D. P., 1 Dec 1997, In : Chemtracts. 10, 9, p. 665-668 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

Kaneko, M., Saito, Y., Saito, H., Matsumoto, T., Matsuda, Y., Vaught, J. L., Dionne, C. A., Angeles, T. S., Glicksman, M. A., Neff, N. T., Rotella, D. P., Kauer, J. C., Mallamo, J. P., Hudkins, R. L. & Murakata, C., 6 Jun 1997, In : Journal of Medicinal Chemistry. 40, 12, p. 1863-1869 7 p.

Research output: Contribution to journalArticle

118 Scopus citations

Phosphinate inhibitors of the D-glutamic acid-adding enzyme of peptidoglycan biosynthesis

Rotella, D. P., 1 Dec 1997, In : Chemtracts. 10, 4, p. 325-327 3 p.

Research output: Contribution to journalArticle

The carboxy termini of β-amyloid peptides I-40 and I-42 are generated by distinct γ-secretase activities

Rotella, D. P., 1 Dec 1997, In : Chemtracts. 10, 9, p. 669-672 4 p.

Research output: Contribution to journalArticle

1996

Facile Lewis Acid-Mediated Ring Opening of 4-Hydroxypyrrolidin-2-ones by Amino Acid Esters

Rotella, D. P., 1 Jan 1996, In : Synlett. 1996, 5, p. 479-480 2 p.

Research output: Contribution to journalArticle

7 Scopus citations