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As a neuroscientist, Dr. Elena Petroff is interested in how brain cells function and how this activity is regulated in physiological and pathophysiological conditions. Ion channel activity is fundamental in the regulation of cell function, from basic membrane transport to complex processes such as signaling, excitability, secretion and cell division. Her previous work has identified a novel mechanism of interaction and mutual regulation by two classes of neuronal and glial ion channels, acid-sensing ion channels (ASICs) and potassium channels. Coordination of ion channel activity and ion channel interaction is an emerging field important for both understanding basic biology and for identifying new pharmacological targets.
Research interests
Interested in how brain cells function and how this activity is regulated in physiological and pathophysiological conditions.
Scholarly Interests
Molecular Neuroscience, Ion Channel Physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Projects
- 1 Finished
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Interaction of ASIC and BK channels and its role in glial proliferation
National Institute of Neurological Disorders and Stroke
15/04/11 → 14/04/15
Project: Research
Research output
- 14 Article
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Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels
Petroff, E., Snitsarev, V., Gong, H. & Abboud, F. M., 5 Oct 2012, In: Biochemical and Biophysical Research Communications. 426, 4, p. 511-515 5 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95
Excoffon, K. J. D. A., Kolawole, A. O., Kusama, N., Gansemer, N. D., Sharma, P., Hruska-Hageman, A. M., Petroff, E. & Benson, C. J., 17 Aug 2012, In: Biochemical and Biophysical Research Communications. 425, 1, p. 13-18 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Acid-sensing ion channels interact with and inhibit BK K+ channels
Petroff, E. Y., Price, M. P., Snitsarev, V., Gong, H., Korovkina, V., Abboud, F. M. & Welsh, M. J., 26 Feb 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 8, p. 3140-3144 5 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus - Mediated gene targeting and somatic cell nuclear transfer
Rogers, C. S., Hao, Y., Rokhlina, T., Samuel, M., Stoltz, D. A., Li, Y., Petroff, E., Vermeer, D. W., Kabel, A. C., Yan, Z., Spate, L., Wax, D., Murphy, C. N., Rieke, A., Whitworth, K., Linville, M. L., Korte, S. W., Engelhardt, J. F., Welsh, M. J. & Prather, R. S., 1 Apr 2008, In: Journal of Clinical Investigation. 118, 4, p. 1571-1577 7 p.Research output: Contribution to journal › Article › peer-review
278 Scopus citations -
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a
Yermolaieva, O., Leonard, A. S., Schnizler, M. K., Abboud, F. M. & Welsh, M. J., 27 Apr 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 17, p. 6752-6757 6 p.Research output: Contribution to journal › Article › peer-review
338 Scopus citations