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Dr. Jinshan Gao's research interests lie in 1) the development of free radical reagents for glycan and protein structure elucidation, 2) the identification and discovery of potential serum biomarkers for cancers, and 3) study of the molecular mechanism of these diseases by combining biomimetic reagents and high-throughput mass spectrometry. His research team recently developed methylated free radical activated glycan sequencing reagent (Me-FRAGS) which significantly simplify the systematic analysis of complex glycan structures using mass spectrometry.
This approach provides valuable information for glycan structure analysis and offers unique advantages compared to earlier studies. In order to apply this approach to the identification of potential glycan biomarkers for cancers, resin-supported and magnetic nanoparticle-based free radical reagent are being designed and synthesized.
Bioinformatics tools for the analysis of DNA (RNA) and protein sequences have been well developed. However, these tools cannot be directly applied to glycan bioinformatics due to the fact that glycan can exhibit complicated branch structures. As with proteomics, mass spectrometry (MS) has been broadly utilized for the characterization of glycans. Unfortunately, no efficient software tools were available to interpret the spectra due to the complexity of glycan structure. Recently, his group has developed free radical reagents for glycan structure characterization. These free radical reagents exhibit high fragmentation efficiency and systematic fragmentation. However, the interpretation of spectra has to be done manually. In order to overcome this barrier, they developed a glycan fragmentation assignment software denominated as “Glyc”.
Research interests
Interests lie in 1) the development of free radical reagents for glycan and protein structure elucidation, 2) the identification and discovery of potential serum biomarkers for cancers, and 3) study of the molecular mechanism of these diseases by combining biomimetic reagents and high-throughput mass spectrometry.
Scholarly Interests
Proteomics and glycomics by employing free radical chemistry and mass spectrometry
Faculty/Media Expert
Expert on mass spectrometry, glycomics, proteomics, and gas-phase free radical.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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RUI: GLYCAN CHARACTERIZATION AND QUANTITATIVE ANALYSIS VIA FREE-RADICAL INDUCED DISSOCIATION
National Science Foundation (NSF)
1/06/17 → 31/05/20
Project: Research
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Characterization of ionized lignin model compounds with α-O-4 linkages by positive- and negative-ion mode electrospray ionization tandem mass spectrometry based on collision-activated dissociation
Sheng, H., Tang, W., Gao, J., Riedeman, J., Hurt, M., Yang, L. & Kenttämaa, H. I., 30 Apr 2021, In: Rapid Communications in Mass Spectrometry. 35, 8, e9057.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Protonated Ground-State Singlet meta-Pyridynes React from an Excited Triplet State
Ma, X., Feng, E., Jiang, H., Boulos, V. M., Gao, J., Nash, J. J. & Kenttämaa, H. I., 19 Feb 2021, In: Journal of Organic Chemistry. 86, 4, p. 3249-3260 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Reactivity of para-benzynes in solution and in the gas phase
Jin, C., Feng, E., Ma, X., Tang, W., Sheng, H., Wittrig, A., Gao, J. & Kenttämaa, H. I., 2021, (Accepted/In press) In: Tetrahedron Letters. 153161.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Chemically enhanced primary treatment of municipal wastewater with ferrate(VI)
Zheng, L., Feng, H., Liu, Y., Gao, J., Sarkar, D. & Deng, Y., 2020, (Accepted/In press) In: Water Environment Research.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Free-Radical-Mediated Glycan Isomer Differentiation
Murtada, R., Fabijanczuk, K., Gaspar, K., Dong, X., Alzarieni, K. Z., Calix, K., Manriquez, E., Bakestani, R. M., Kenttämaa, H. I. & Gao, J., 20 Oct 2020, In: Analytical Chemistry. 92, 20, p. 13794-13802 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations