• Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
20052021

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

University profile

Dr. Jinshan Gao's research interests lie in 1) the development of free radical reagents for glycan and protein structure elucidation, 2) the identification and discovery of potential serum biomarkers for cancers, and 3) study of the molecular mechanism of these diseases by combining biomimetic reagents and high-throughput mass spectrometry. His research team recently developed methylated free radical activated glycan sequencing reagent (Me-FRAGS) which significantly simplify the systematic analysis of complex glycan structures using mass spectrometry.

This approach provides valuable information for glycan structure analysis and offers unique advantages compared to earlier studies. In order to apply this approach to the identification of potential glycan biomarkers for cancers, resin-supported and magnetic nanoparticle-based free radical reagent are being designed and synthesized.

Bioinformatics tools for the analysis of DNA (RNA) and protein sequences have been well developed. However, these tools cannot be directly applied to glycan bioinformatics due to the fact that glycan can exhibit complicated branch structures. As with proteomics, mass spectrometry (MS) has been broadly utilized for the characterization of glycans. Unfortunately, no efficient software tools were available to interpret the spectra due to the complexity of glycan structure. Recently, his group has developed free radical reagents for glycan structure characterization. These free radical reagents exhibit high fragmentation efficiency and systematic fragmentation. However, the interpretation of spectra has to be done manually. In order to overcome this barrier, they developed a glycan fragmentation assignment software denominated as “Glyc”. 

Research interests

Interests lie in 1) the development of free radical reagents for glycan and protein structure elucidation, 2) the identification and discovery of potential serum biomarkers for cancers, and 3) study of the molecular mechanism of these diseases by combining biomimetic reagents and high-throughput mass spectrometry.

Scholarly Interests

Proteomics and glycomics by employing free radical chemistry and mass spectrometry
 

Faculty/Media Expert

Expert on mass spectrometry, glycomics, proteomics, and gas-phase free radical.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 7 - Affordable and Clean Energy
  • SDG 11 - Sustainable Cities and Communities

Fingerprint

Dive into the research topics where Jinshan Gao is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Network

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or