• 5073 Citations
  • 34 h-Index
1973 …2018
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Fingerprint Dive into the research topics where John Siekierka is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Tacrolimus Medicine & Life Sciences
Tacrolimus Binding Proteins Medicine & Life Sciences
Immunosuppressive Agents Medicine & Life Sciences
p38 Mitogen-Activated Protein Kinases Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Eukaryotic Initiation Factor-2 Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Peptidylprolyl Isomerase Medicine & Life Sciences

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Research Output 1973 2018

1 Citation (Scopus)

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. & Rotella, D., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

Filarial Elephantiasis
Structure-Activity Relationship
Protein Kinase Inhibitors
Heat-Shock Proteins
Protein Kinases
1 Citation (Scopus)

Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase

Perez-Abraham, R., Sanchez, K. G., Alfonso, M., Gubler, U., Siekierka, J. J. & Goodey, N. M., 1 Dec 2016, In : Protein Expression and Purification. 128, p. 81-85 5 p.

Research output: Contribution to journalArticle

Brugia malayi
Tetrahydrofolate Dehydrogenase
Neglected Diseases
Filarial Elephantiasis
Folic Acid Antagonists
15 Citations (Scopus)

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Brumlik, M. J., Nkhoma, S., Kious, M. J., Thompson, G. R., Patterson, T. F., Siekierka, J. J., Anderson, T. J. C. & Curiel, T. J., 1 Jun 2011, In : Experimental Parasitology. 128, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Plasmodium falciparum
Protein Kinase Inhibitors
Encephalitozoon cuniculi
11 Citations (Scopus)

The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses

Patel, A., Chojnowski, A. N., Gaskill, K., De Martini, W., Goldberg, R. L. & Siekierka, J. J., 1 Apr 2011, In : Molecular and Biochemical Parasitology. 176, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

Brugia malayi
p38 Mitogen-Activated Protein Kinases
Oxidative Stress
Reactive Oxygen Species

Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets

Liotta, F. & Siekierka, J. J., 1 Feb 2010, In : Current Opinion in Investigational Drugs. 11, 2, p. 147-156 10 p.

Research output: Contribution to journalReview article

Antiparasitic Agents
Parasitic Diseases
Protein Kinases