• 5165 Citations
  • 35 h-Index
1973 …2018

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2018

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. J. & Rotella, D. P., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase

Perez-Abraham, R., Sanchez, K. G., Alfonso, M., Gubler, U., Siekierka, J. J. & Goodey, N. M., 1 Dec 2016, In : Protein Expression and Purification. 128, p. 81-85 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Brumlik, M. J., Nkhoma, S., Kious, M. J., Thompson, G. R., Patterson, T. F., Siekierka, J. J., Anderson, T. J. C. & Curiel, T. J., 1 Jun 2011, In : Experimental Parasitology. 128, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses

Patel, A., Chojnowski, A. N., Gaskill, K., De Martini, W., Goldberg, R. L. & Siekierka, J. J., 1 Apr 2011, In : Molecular and Biochemical Parasitology. 176, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2007

Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection

Wei, S., Daniel, B. J., Brumlik, M. J., Burow, M. E., Zou, W., Khan, I. A., Wadsworth, S., Siekierka, J. & Curiel, T. J., 1 Dec 2007, In : Antimicrobial Agents and Chemotherapy. 51, 12, p. 4324-4328 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2006

A multiplexed proteomics approach to differentiate neurite outgrowth patterns

Liu, T., D'mello, V., Deng, L., Hu, J., Ricardo, M., Pan, S., Lu, X., Wadsworth, S., Siekierka, J., Birge, R. & Li, H., 15 Nov 2006, In : Journal of Neuroscience Methods. 158, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effects of drug combinations on smooth muscle cell proliferation: An isobolographic analysis

Parry, T. J., Thyagarajan, R., Argentieri, D., Falotico, R., Siekierka, J. & Tallarida, R. J., 17 Feb 2006, In : European Journal of Pharmacology. 532, 1-2, p. 38-43 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibitors of unactivated p38 MAP kinase

Bullington, J., Argentieri, D., Averill, K., Carter, D., Cavender, D., Fahmy, B., Fan, X., Hall, D., Heintzelman, G., Jackson, P., Leung, W. P., Li, X., Ling, P., Olini, G., Razler, T., Reuman, M., Rupert, K., Russell, R., Siekierka, J., Wadsworth, S. & 3 others, Wolff, R., Xiang, B. & Zhang, Y. M., 1 Dec 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 23, p. 6102-6106 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2005

Drug-eluting stents: Sirolimus and paclitaxel differentially affect cultured cells and injured arteries

Parry, T. J., Brosius, R., Thyagarajan, R., Carter, D., Argentieri, D., Falotico, R. & Siekierka, J., 7 Nov 2005, In : European Journal of Pharmacology. 524, 1-3, p. 19-29 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Muthumani, K., Choo, A. Y., Hwang, D. S., Premkumar, A., Dayes, N. S., Harris, C., Green, D. R., Wadsworth, S. A., Siekierka, J. J. & Weiner, D. B., 15 Sep 2005, In : Blood. 106, 6, p. 2059-2068 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2004

A novel role for the immunophilin FKBP52 in copper transport

Sanokawa-Akakura, R., Dai, H., Akakura, S., Weinstein, D., Fajardo, J. E., Lang, S. E., Wadsworth, S., Siekierka, J. & Birge, R. B., 2 Jul 2004, In : Journal of Biological Chemistry. 279, 27, p. 27845-27848 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

A role for schwann cells in the neuroregenerative effects of a non-immunosuppressive FK506 derivative, JNJ460

Birge, R. B., Wadsworth, S., Akakura, R., Abeysinghe, H., Kanojia, R., Macielag, M., Desbarats, J., Escalante, M., Singh, K., Sundarababu, S., Parris, K., Childs, G., August, A., Siekierka, J. & Weinstein, D. E., 1 Jan 2004, In : Neuroscience. 124, 2, p. 351-366 16 p.

Research output: Contribution to journalArticle

35 Scopus citations

Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

Muthumani, K., Wadsworth, S. A., Dayes, N. S., Hwang, D. S., Choo, A. Y., Abeysinghe, H. R., Siekierka, J. J. & Weiner, D. B., 26 Mar 2004, In : AIDS. 18, 5, p. 739-748 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Rupert, K. C., Henry, J. R., Dodd, J. H., Wadsworth, S. A., Cavender, D. E., Olini, G. C., Fahmy, B. & Siekierka, J. J., 1 Feb 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 3, p. 347-350 4 p.

Research output: Contribution to journalArticle

206 Scopus citations
2002

Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells

Tao, L., Wadsworth, S., Mercer, J., Mueller, C., Lynn, K., Siekierka, J. & August, A., 1 Apr 2002, In : Biochemical Journal. 363, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2001

Kinetics of small molecule inhibitor binding to p38 kinase

Thurmond, R. L., Wadsworth, S. A., Schafer, P. H., Zivin, R. A. & Siekierka, J. J., 3 Dec 2001, In : European Journal of Biochemistry. 268, 22, p. 5747-5754 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
1999

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J. J., Peterson, P. A. & Fung-Leung, W. P., 5 Apr 1999, In : Journal of Experimental Medicine. 189, 7, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

136 Scopus citations

p38α Mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

Schafer, P. H., Wadsworth, S. A., Wang, L. & Siekierka, J. J., 15 Jun 1999, In : Journal of Immunology. 162, 12, p. 7110-7119 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

Wadsworth, S. A., Cavender, D. E., Beers, S. A., Lalan, P., Schafer, P. H., Malloy, E. A., Wu, W., Fahmy, B., Olini, G. C., Davis, J. E., Pellegrino-Gensey, J. L., Wachter, M. P. & Siekierka, J. J., 1 Nov 1999, In : Journal of Pharmacology and Experimental Therapeutics. 291, 2, p. 680-687 8 p.

Research output: Contribution to journalArticle

148 Scopus citations

T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-α production in a manner distinct from LPS activation of monocytes

Schafer, P. H., Wang, L., Wadsworth, S. A., Davis, J. E. & Siekierka, J. J., 15 Jan 1999, In : Journal of Immunology. 162, 2, p. 659-668 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
1998

Detergent-salt resistance of LAP2α in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

Dechat, T., Gotzmann, J., Stockinger, A., Harris, C. A., Talle, M. A., Siekierka, J. J. & Foisner, R., 17 Aug 1998, In : EMBO Journal. 17, 16, p. 4887-4902 16 p.

Research output: Contribution to journalArticle

115 Scopus citations

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

Kanakaraj, P., Schafer, P. H., Cavender, D. E., Wu, Y., Ngo, K., Grealish, P. F., Wadsworth, S. A., Peterson, P. A., Siekierka, J. J., Harris, C. A. & Fung-Leung, W. P., 15 Jun 1998, In : Journal of Experimental Medicine. 187, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

170 Scopus citations

Irak requirement for optimal induction by IL-I of multiple signaling pathways

Kanakaraji, P., Schafer, P. H., Cavender, D., Ngo, K., Wul, Y., Grealish, F. F., Wadsworth, S. A., Peterson, P. A., Siekierka, J. J., Harris, C. A. & Fung-Leungl, W. P., 1 Dec 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

Potent inhibitors of the MAP kinase p38

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., Schafer, P. H. & Siekierka, J. J., 1 Dec 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 23, p. 3335-3340 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

The development of novel and selective p56(lck) tyrosine kinase inhibitors

Bullington, J. L., Cameron, J. C., Davis, J. E., Dodd, J. H., Harris, C. A., Henry, J. R., Pellegrino-Gensey, J. L., Rupert, K. C. & Siekierka, J. J., 22 Sep 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 18, p. 2489-2494 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Yeast immunophilins: Purification and assay of yeast FKBP12

Wiederrecht, G. & Siekierka, J. J., 1 Jan 1998, In : Methods in Enzymology. 290, p. 74-84 11 p.

Research output: Contribution to journalArticle

1997

Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45

Beers, S. A., Malloy, E. A., Wu, W., Wachter, M. P., Gunnia, U., Cavender, D., Harris, C., Davis, J., Brosius, R., Pellegrino-Gensey, J. L. & Siekierka, J., 1 Dec 1997, In : Bioorganic and Medicinal Chemistry. 5, 12, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

T cell activation signals upregulate p38 map k1nase activity

Wang, L., Schäfer, P. H., Davis, J. K., Wads Worth, S. A. & Siekierka, J. J., 1 Dec 1997, In : FASEB Journal. 11, 9, p. A1167

Research output: Contribution to journalArticle

1996
1 Scopus citations
1995

Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO β to rat lamin-associated polypeptide 2

Harris, C. A., Andryuk, P. J., Cline, S. W., Mathew, S., Siekierka, J. J. & Goldstein, G., 20 Jul 1995, In : Genomics. 28, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
1994

Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Goulet, M. T., Hodkey, D. W., Staruch, M. J., Dumont, F. J., Lin, S., Hung, S. H. Y., Siekierka, J. J. & Wyvratt, M. J., 1994, In : Bioorganic and Medicinal Chemistry Letters. 4, 7, p. 927-930 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

Siekierka, J. J., 1 Jun 1994, In : Immunologic Research. 13, 2-3, p. 110-116 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Three distinct human thymopoietins are derived from alternatively spliced mRNAs

Harris, C. A., Andryuk, P. J., Cline, S., Karen Chan, H., Natarajan, A., Siekierka, J. J. & Goldstein, G., 5 Jul 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 14, p. 6283-6287 5 p.

Research output: Contribution to journalArticle

99 Scopus citations
1993

Rapamycin-induced inhibition of p34(cdc2) kinase activation is associated with G1/S-phase growth arrest in T lymphocytes

Morice, W. G., Brunn, G. J., Wiederrecht, G., Siekierka, J. J. & Abraham, R. T., 1 Jan 1993, In : Journal of Biological Chemistry. 268, 5, p. 3734-3738 5 p.

Research output: Contribution to journalArticle

168 Scopus citations

Rapamycin inhibition of interleukin-2-dependent p33(cdk2) and p34(cdc2) kinase activation in T lymphocytes

Morice, W. G., Wiederrecht, G., Brunn, G. J., Siekierka, J. J. & Abraham, R. T., 1 Jan 1993, In : Journal of Biological Chemistry. 268, 30, p. 22737-22745 9 p.

Research output: Contribution to journalArticle

134 Scopus citations
1992

Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex

Wiederrecht, G., Hung, S., Chan, H. K., Marcy, A., Martin, M., Calaycay, J., Boulton, D., Sigal, N., Kincaid, R. L. & Siekierka, J. J., 11 Nov 1992, In : Journal of Biological Chemistry. 267, 30, p. 21753-21760 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond

Siekierka, J. J. & Sigal, N. H., 1992, In : Current Opinion in Immunology. 4, 5, p. 548-552 5 p.

Research output: Contribution to journalArticle

74 Scopus citations

Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein

Wiederrecht, G., Martin, M. M., Sigal, N. H. & Siekierka, J. J., 29 May 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 298-303 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin

Dumont, F. J., Staruch, M. J., Koprak, S. L., Siekierka, J. J., Lin, C. S., Harrison, R., Sewell, T., Kindt, V. M., Beattie, T. R., Wyvratt, M. & Sigal, N. H., 1 Sep 1992, In : Journal of Experimental Medicine. 176, 3, p. 751-760 10 p.

Research output: Contribution to journalArticle

223 Scopus citations

Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2

Nielsen, J. B., Foor, F., Siekierka, J. J., Hsu, M. J., Ramadan, N., Morin, N., Shafiee, A., Dahl, A. M., Brizuela, L., Chrebet, G., Bostian, K. A. & Parent, S. A., 1 Jan 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7471-7475 5 p.

Research output: Contribution to journalArticle

49 Scopus citations
1991

FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

Lin, C. S., Boltz, R. C., Siekierka, J. J. & Sigal, N. H., 1 Apr 1991, In : Cellular Immunology. 133, 2, p. 269-284 16 p.

Research output: Contribution to journalArticle

107 Scopus citations

FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins

Wiederrecht, G., Brizuela, L., Elliston, K., Sigal, N. H. & Siekierka, J. J., 21 Feb 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 3, p. 1029-1033 5 p.

Research output: Contribution to journalArticle

78 Scopus citations

FKBP, the binding protein for the immunosuppressive drug, FK-506, is not an inhibitor of protein kinase C activity

Cryan, J., Hung, S. H. Y., Wiederrecht, G., Sigal, N. H. & Siekierka, J. J., 31 Oct 1991, In : Biochemical and Biophysical Research Communications. 180, 2, p. 846-852 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A

Sigal, N. H., Lin, C. S. & Siekierka, J. J., 17 May 1991, In : Transplantation Proceedings. 23, 2 SUPPL. 2, p. 1-5 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

Sigal, N. H., Dumont, F., Durette, P., Siekierka, J. J., Peterson, L., Rich, D. H., Dunlap, B. E., Staruch, M. J., Melino, M. R., Koprak, S. L., Williams, D., Witzel, B. & Pisano, J. M., 1 Jan 1991, In : Journal of Experimental Medicine. 173, 3, p. 619-628 10 p.

Research output: Contribution to journalArticle

221 Scopus citations

Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?

Sigal, N. H., Dumont, F. J., Siekierka, J. J., Wiederrecht, G., Parent, S. A. & Brizuela, L., 1 Dec 1991, In : Transplantation Proceedings. 23, 6, p. 2846-2849 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Potential roles of other FK 506-binding proteins in mediating the effects of FK 506

Siekierka, J. J., Wiederrecht, G., Cryan, J., Hung, S. H. Y., Comisky, M. & Sigal, N. H., 1 Dec 1991, In : Transplantation Proceedings. 23, 6, p. 2720-2721 2 p.

Research output: Contribution to journalArticle

7 Scopus citations
1990

Observations on the mechanism of action of FK-506. A pharmacologic probe of lymphocyte signal transduction

Sigal, N. H., Siekierka, J. J. & Dumont, F. J., 15 Nov 1990, In : Biochemical Pharmacology. 40, 10, p. 2201-2208 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase

Siekierka, J. J., Wiederrecht, G., Greulich, H., Boulton, D., Hung, S. H. Y., Cryan, J., Hodges, P. J. & Sigal, N. H., 1 Dec 1990, In : Journal of Biological Chemistry. 265, 34, p. 21011-21015 5 p.

Research output: Contribution to journalArticle

105 Scopus citations
1989

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S. & Sigal, N. H., 1 Jan 1989, In : Nature. 341, 6244, p. 755-757 3 p.

Research output: Contribution to journalArticle

837 Scopus citations