6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354)

A potent and selective p38 kinase inhibitor [4]

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Bohumila Fahmy, Gilbert C. Olini, Janet E. Davis, J. Lee Pellegrino-Gensey, Peter H. Schafer, John Siekierka

Research output: Contribution to journalLetterResearchpeer-review

74 Citations (Scopus)
Original languageEnglish
Pages (from-to)4196-4198
Number of pages3
JournalJournal of Medicinal Chemistry
Volume41
Issue number22
DOIs
StatePublished - 23 Oct 1998

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Aminopyridines
Calcium-Calmodulin-Dependent Protein Kinases
Pyrroles
T-cells
Enzyme Inhibitors
p38 Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases
Interleukin-1
Lipopolysaccharides
Rats
Animals
Phosphotransferases
Tumor Necrosis Factor-alpha
RWJ 68354

Cite this

Henry, James R. ; Rupert, Kenneth C. ; Dodd, John H. ; Turchi, Ignatius J. ; Wadsworth, Scott A. ; Cavender, Druie E. ; Fahmy, Bohumila ; Olini, Gilbert C. ; Davis, Janet E. ; Lee Pellegrino-Gensey, J. ; Schafer, Peter H. ; Siekierka, John. / 6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354) : A potent and selective p38 kinase inhibitor [4]. In: Journal of Medicinal Chemistry. 1998 ; Vol. 41, No. 22. pp. 4196-4198.
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title = "6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354): A potent and selective p38 kinase inhibitor [4]",
author = "Henry, {James R.} and Rupert, {Kenneth C.} and Dodd, {John H.} and Turchi, {Ignatius J.} and Wadsworth, {Scott A.} and Cavender, {Druie E.} and Bohumila Fahmy and Olini, {Gilbert C.} and Davis, {Janet E.} and {Lee Pellegrino-Gensey}, J. and Schafer, {Peter H.} and John Siekierka",
year = "1998",
month = "10",
day = "23",
doi = "10.1021/jm980497b",
language = "English",
volume = "41",
pages = "4196--4198",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
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Henry, JR, Rupert, KC, Dodd, JH, Turchi, IJ, Wadsworth, SA, Cavender, DE, Fahmy, B, Olini, GC, Davis, JE, Lee Pellegrino-Gensey, J, Schafer, PH & Siekierka, J 1998, '6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354): A potent and selective p38 kinase inhibitor [4]', Journal of Medicinal Chemistry, vol. 41, no. 22, pp. 4196-4198. https://doi.org/10.1021/jm980497b

6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354) : A potent and selective p38 kinase inhibitor [4]. / Henry, James R.; Rupert, Kenneth C.; Dodd, John H.; Turchi, Ignatius J.; Wadsworth, Scott A.; Cavender, Druie E.; Fahmy, Bohumila; Olini, Gilbert C.; Davis, Janet E.; Lee Pellegrino-Gensey, J.; Schafer, Peter H.; Siekierka, John.

In: Journal of Medicinal Chemistry, Vol. 41, No. 22, 23.10.1998, p. 4196-4198.

Research output: Contribution to journalLetterResearchpeer-review

TY - JOUR

T1 - 6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354)

T2 - A potent and selective p38 kinase inhibitor [4]

AU - Henry, James R.

AU - Rupert, Kenneth C.

AU - Dodd, John H.

AU - Turchi, Ignatius J.

AU - Wadsworth, Scott A.

AU - Cavender, Druie E.

AU - Fahmy, Bohumila

AU - Olini, Gilbert C.

AU - Davis, Janet E.

AU - Lee Pellegrino-Gensey, J.

AU - Schafer, Peter H.

AU - Siekierka, John

PY - 1998/10/23

Y1 - 1998/10/23

UR - http://www.scopus.com/inward/record.url?scp=7844222102&partnerID=8YFLogxK

U2 - 10.1021/jm980497b

DO - 10.1021/jm980497b

M3 - Letter

VL - 41

SP - 4196

EP - 4198

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 22

ER -