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Author

  • David Rotella
2018

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Tummalapalli, S. R., Bhat, R., Chojnowski, A., Prorok, M., Kreiss, T., Goldberg, R., Canan, S., Hawryluk, N., Mortensen, D., Khetani, V., Zeldis, J., Siekierka, J. J. & Rotella, D. P., 8 Mar 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Tobias, A. M., Toska, D., Lange, K., Eck, T., Bhat, R., Janson, C. A., Rotella, D. P., Gubler, U. & Goodey, N. M., May 2018, In : PLoS ONE. 13, 5, e0197173.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Comprehensive Medicinal Chemistry III

Chackalamannil, S., Rotella, D. P. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. 1-4369 4369 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds

Minnow, Y. V. T., Goldberg, R., Tummalapalli, S. R., Rotella, D. P. & Goodey, N. M., 15 Mar 2017, In : Archives of Biochemistry and Biophysics. 618, p. 15-22 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Preface

Chackalamannil, S., Rotella, D. P. & Ward, S. E., 3 Jun 2017, The Future of Drug Discovery: Drug Discovery Technologies: In Silico Drug Discovery Tools: Experimental Adme and Toxicology: Cancer, Immunology and Inflammation, and Infectious Disease: Biologics Medicine: Cns, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence: Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 1-8. p. v-vi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Synthesis and computational analysis of conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines

Tummalapalli, S. R., Bhat, R., Waitt, C., Eshuis, H. & Rotella, D. P., 1 Jan 2017, In : Tetrahedron Letters. 58, 43, p. 4087-4089 3 p.

Research output: Contribution to journalArticle

2016

The Critical Role of Organic Chemistry in Drug Discovery

Rotella, D. P., 19 Oct 2016, In : ACS Chemical Neuroscience. 7, 10, p. 1315-1316 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations
2015

Preface

Fischer, J. & Rotella, D. P., 30 Jan 2015, Successful Drug Discovery. wiley, p. XIII-XV

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Serendipitous target-based drug discoveries

Fischer, J. & Rotella, D. P., 30 Jan 2015, Successful Drug Discovery. wiley, p. 3-18 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Successful drug discovery

Fischer, J. & Rotella, D. P., 30 Jan 2015, wiley. 235 p.

Research output: Book/ReportBook

1 Scopus citations
2014

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Bhat, R., Tummalapalli, S. R. & Rotella, D. P., 13 Nov 2014, In : Journal of Medicinal Chemistry. 57, 21, p. 8718-8728 11 p.

Research output: Contribution to journalReview article

83 Scopus citations

Recent Results In Phosphodiesterase Inhibitor Development and CNS Applications

Rotella, D. P., 28 Apr 2014, Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. Wiley Blackwell, p. 115-144 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Deloison, G., Rouillé, Y., Séron, K. & Rotella, D. P., 1 Sep 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4162-4165 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

Bhat, R., Adam, A. T., Lee, J. J., Gasiewicz, T. A., Henry, E. C. & Rotella, D. P., 15 May 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 10, p. 2263-2266 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

The discovery and development of boceprevir

Rotella, D. P., 1 Nov 2013, In : Expert Opinion on Drug Discovery. 8, 11, p. 1439-1447 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: Dependence on solvent polarity

Snitsarev, V., Young, M. N., Miller, R. M. S. & Rotella, D. P., 22 Nov 2013, In : PLoS ONE. 8, 11, e79834.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Analogue-Based Drug Discovery III

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Wiley-VCH.

Research output: Book/ReportBook

8 Scopus citations

Drug discovery 2012 and beyond

Rotella, D. P., 8 Mar 2012, In : ACS Medicinal Chemistry Letters. 3, 3, p. 172-173 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Pioneer and Analogue Drugs

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. 1-19 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Preface

Fischer, J., Ganellin, C. R. & Rotella, D. P., 18 Dec 2012, Analogue-Based Drug Discovery III. Wiley-VCH, p. xiii-xiv

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Recent results in protein kinase inhibition for tropical diseases

Rotella, D. P., 15 Nov 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 22, p. 6788-6793 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Welcome to pharmaceutical patent analyst

Jones, L. H., Rotella, D. P. & Doca, G., 1 Jan 2012, In : Pharmaceutical Patent Analyst. 1, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations