A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference

Ruth Propper, Lauren J. O'Donnell, Stephen Whalen, Yanmei Tie, Isaiah H. Norton, Ralph O. Suarez, Lilla Zollei, Alireza Radmanesh, Alexandra J. Golby

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca's and Wernicke's areas, and structural measures of the arcuate fasciculus. Results revealed an effect of degree of hand preference on arcuate fasciculus structure, such that consistently-handed individuals, regardless of the direction of hand preference, demonstrated the most asymmetric arcuate fasciculus, with larger left versus right arcuate, as measured by DTI. Functional language lateralization in Wernicke's area, measured via fMRI, was related to arcuate fasciculus volume in consistent-left-handers only, and only in people who were not right hemisphere lateralized for language; given the small sample size for this finding, future investigation is warranted. Results suggest handedness degree may be an important variable to investigate in the context of neuroanatomical asymmetries.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalBrain and Cognition
Volume73
Issue number2
DOIs
StatePublished - 1 Jul 2010

Fingerprint

Language
Hand
Magnetic Resonance Imaging
Functional Laterality
Sample Size
Direction compound
Functional Magnetic Resonance Imaging
Language Lateralization
Wernicke's Area
Wernicke Area
Right Hemisphere
Handedness
Small Sample
Asymmetry
Broca's Area
Broca Area

Keywords

  • Arcuate fasciculus
  • DTI
  • FMRI
  • Handedness
  • Language

Cite this

Propper, Ruth ; O'Donnell, Lauren J. ; Whalen, Stephen ; Tie, Yanmei ; Norton, Isaiah H. ; Suarez, Ralph O. ; Zollei, Lilla ; Radmanesh, Alireza ; Golby, Alexandra J. / A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure : Effects of degree versus direction of hand preference. In: Brain and Cognition. 2010 ; Vol. 73, No. 2. pp. 85-92.
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A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure : Effects of degree versus direction of hand preference. / Propper, Ruth; O'Donnell, Lauren J.; Whalen, Stephen; Tie, Yanmei; Norton, Isaiah H.; Suarez, Ralph O.; Zollei, Lilla; Radmanesh, Alireza; Golby, Alexandra J.

In: Brain and Cognition, Vol. 73, No. 2, 01.07.2010, p. 85-92.

Research output: Contribution to journalArticle

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