The fifth edition of the Diagnostic and Statistical Manual (DSM-5) was recently released and it contains significant cultural revisions in comparison to the DSM-IV. In this article, the research, assessment, and psychotherapeutic implications of these changes for cultural minorities are examined. The DSM-5's cultural revisions are categorized into 2 types: modifications that are an extension of previous revisions and changes that resulted from the DSM-5's overall restructuring. A cultural framework is used to analyze these revisions. In addition, throughout this article suggestions for the development of a more culturally sensitive and inclusive DSM are discussed. To conclude some of the main research and clinical implications of DSM-5's cultural revisions are underscored.