A rodent model of premenstrual dysphoria

Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

Yan Li, Alan Pehrson, David P. Budac, Connie Sánchez, Maria Gulinello

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Premenstrual dysphoric disorder (PMDD) is characterized by a range of physical and affective symptoms including anxiety, irritability, anhedonia, social withdrawal and depression. We demonstrate robust and reproducible depression-like behavior during progesterone withdrawal (PWD) protocols with different methodological variables. Comparable immobility in the forced swim test was evident with different routes of administration (i.e. injections vs. implants), with and without exogenous estrogens in addition to progesterone, and in both single and multiple withdrawal paradigms. Furthermore, withdrawal from physiological doses of progesterone resulted in modest social withdrawal in the social preference test and anhedonia in the saccharin preference test without altering general activity levels or total liquid consumption. However, progesterone withdrawal did not alter serotonin levels in the cortex or hippocampus. Furthermore tryptophan depletion did not augment immobility during PWD. Neither fluoxetine nor duloxetine reduced depression-like behavior during PWD in the forced swim test. In contrast, the tricyclic antidepressant, amitriptyline, was effective in reducing the immobility in forced swim test. These data demonstrate that progesterone withdrawal is a reproducible model of PMDD in several critical behavioral domains. Furthermore, these data do not support alterations in serotonin levels in the etiology of hormonally induced depression.

Original languageEnglish
Pages (from-to)238-247
Number of pages10
JournalBehavioural Brain Research
Volume234
Issue number2
DOIs
StatePublished - 1 Oct 2012

Fingerprint

Antidepressive Agents
Progesterone
Rodentia
Depression
Anhedonia
Serotonin
Saccharin
Amitriptyline
Affective Symptoms
Tricyclic Antidepressive Agents
Fluoxetine
Tryptophan
Hippocampus
Estrogens
Anxiety
Injections

Keywords

  • Amitriptyline
  • Anhedonia
  • Antidepressant
  • Depression
  • Duloxetine
  • Female
  • Fluoxetine
  • Forced swim
  • Premenstrual dysphoria
  • Progesterone withdrawal
  • Rat
  • Social preference

Cite this

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title = "A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants",
abstract = "Premenstrual dysphoric disorder (PMDD) is characterized by a range of physical and affective symptoms including anxiety, irritability, anhedonia, social withdrawal and depression. We demonstrate robust and reproducible depression-like behavior during progesterone withdrawal (PWD) protocols with different methodological variables. Comparable immobility in the forced swim test was evident with different routes of administration (i.e. injections vs. implants), with and without exogenous estrogens in addition to progesterone, and in both single and multiple withdrawal paradigms. Furthermore, withdrawal from physiological doses of progesterone resulted in modest social withdrawal in the social preference test and anhedonia in the saccharin preference test without altering general activity levels or total liquid consumption. However, progesterone withdrawal did not alter serotonin levels in the cortex or hippocampus. Furthermore tryptophan depletion did not augment immobility during PWD. Neither fluoxetine nor duloxetine reduced depression-like behavior during PWD in the forced swim test. In contrast, the tricyclic antidepressant, amitriptyline, was effective in reducing the immobility in forced swim test. These data demonstrate that progesterone withdrawal is a reproducible model of PMDD in several critical behavioral domains. Furthermore, these data do not support alterations in serotonin levels in the etiology of hormonally induced depression.",
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A rodent model of premenstrual dysphoria : Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants. / Li, Yan; Pehrson, Alan; Budac, David P.; Sánchez, Connie; Gulinello, Maria.

In: Behavioural Brain Research, Vol. 234, No. 2, 01.10.2012, p. 238-247.

Research output: Contribution to journalArticleResearchpeer-review

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