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Keyphrases
Repurposing
100%
Antifolate
100%
Wuchereria Bancrofti
100%
DHFR Inhibitors
100%
W. Bancrofti
100%
Virtual Screening
100%
Methylenetetrahydrofolate Reductase (MTHFR)
66%
Methotrexate
50%
Virtual Screening Workflows
33%
Experimental Validation
16%
Binding Site
16%
DNA Synthesis
16%
Lymphatic Filariasis
16%
Structural Information
16%
Drug Discovery
16%
Crystallographic Study
16%
Hydrogen Bonds (H-bonds)
16%
Folate
16%
Putative Drug Targets
16%
Global Health Issue
16%
High-resolution Structures
16%
Binding Interaction
16%
Protein Data Bank
16%
Folate Metabolism
16%
Dihydrofolate Reductase Inhibitors
16%
Neglected Tropical Diseases
16%
Docking Score
16%
Inhibition Assay
16%
Nanomolar Activity
16%
Ki-1
16%
Chemistry
Dihydrofolates
100%
Antifolate
100%
Virtual Screening
100%
Methotrexate
75%
Folate
50%
Drug Discovery
25%
Binding Site
25%
Hydrogen Bonding
25%
DNA
25%
Parasitic
25%
Dihydrofolate Reductase Inhibitor
25%
Inhibition Constant (Ki)
25%
Pharmacology, Toxicology and Pharmaceutical Science
Folic Acid Antagonist
100%
Wuchereria bancrofti
100%
Virtual Screening
100%
Dihydrofolate Reductase
83%
Methotrexate
50%
Binding Site
16%
Lymphatic Filariasis
16%
Drug Discovery
16%
Hydrogen Bond
16%
Dihydrofolate Reductase Inhibitor
16%
Folic Acid
16%
Tropical Disease
16%