Acid Phosphatase Activity in Human Breast Tumors

Reginald Halaby, Jafar Abdollahi, Minerva L. Martinez

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC.

Original languageEnglish
Article numberE002
JournalBreast Cancer Research
Volume3
Issue number2
DOIs
StatePublished - 1 Apr 2001

Fingerprint

Acid Phosphatase
Human Activities
Ductal Carcinoma
Breast Neoplasms
Breast
Carcinoma, Intraductal, Noninfiltrating
Epithelium
Staining and Labeling
Biopsy
Enzymes
Neoplasms

Keywords

  • Acid phosphatase
  • Breast cancer
  • Ductal carcinoma in situ
  • Invasive ductal carcinoma
  • Lysosomes

Cite this

Halaby, Reginald ; Abdollahi, Jafar ; Martinez, Minerva L. / Acid Phosphatase Activity in Human Breast Tumors. In: Breast Cancer Research. 2001 ; Vol. 3, No. 2.
@article{e230d47fd3624e9883069774c5ddecaa,
title = "Acid Phosphatase Activity in Human Breast Tumors",
abstract = "We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC.",
keywords = "Acid phosphatase, Breast cancer, Ductal carcinoma in situ, Invasive ductal carcinoma, Lysosomes",
author = "Reginald Halaby and Jafar Abdollahi and Martinez, {Minerva L.}",
year = "2001",
month = "4",
day = "1",
doi = "10.1186/bcr296",
language = "English",
volume = "3",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "2",

}

Acid Phosphatase Activity in Human Breast Tumors. / Halaby, Reginald; Abdollahi, Jafar; Martinez, Minerva L.

In: Breast Cancer Research, Vol. 3, No. 2, E002, 01.04.2001.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Acid Phosphatase Activity in Human Breast Tumors

AU - Halaby, Reginald

AU - Abdollahi, Jafar

AU - Martinez, Minerva L.

PY - 2001/4/1

Y1 - 2001/4/1

N2 - We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC.

AB - We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC.

KW - Acid phosphatase

KW - Breast cancer

KW - Ductal carcinoma in situ

KW - Invasive ductal carcinoma

KW - Lysosomes

UR - http://www.scopus.com/inward/record.url?scp=85009964683&partnerID=8YFLogxK

U2 - 10.1186/bcr296

DO - 10.1186/bcr296

M3 - Article

VL - 3

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 2

M1 - E002

ER -