Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

Jërg H. Stehle, Nicholas S. Foulkes, Carlos Molina, Valérie Simonneaux, Paul Pévet, Paolo Sassone-Corsi

Research output: Contribution to journalArticleResearchpeer-review

343 Citations (Scopus)

Abstract

Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalNature
Volume365
Issue number6444
DOIs
StatePublished - 1 Jan 1993

Fingerprint

Pineal Gland
Melatonin
Cyclic AMP
Adrenergic Agents
Signal Transduction
Protein Isoforms
Transcription Factors
Hormones

Cite this

Stehle, J. H., Foulkes, N. S., Molina, C., Simonneaux, V., Pévet, P., & Sassone-Corsi, P. (1993). Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature, 365(6444), 314-320. https://doi.org/10.1038/365314a0
Stehle, Jërg H. ; Foulkes, Nicholas S. ; Molina, Carlos ; Simonneaux, Valérie ; Pévet, Paul ; Sassone-Corsi, Paolo. / Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. In: Nature. 1993 ; Vol. 365, No. 6444. pp. 314-320.
@article{90e60ec330d94d87a27cd3c567294067,
title = "Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland",
abstract = "Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.",
author = "Stehle, {J{\"e}rg H.} and Foulkes, {Nicholas S.} and Carlos Molina and Val{\'e}rie Simonneaux and Paul P{\'e}vet and Paolo Sassone-Corsi",
year = "1993",
month = "1",
day = "1",
doi = "10.1038/365314a0",
language = "English",
volume = "365",
pages = "314--320",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6444",

}

Stehle, JH, Foulkes, NS, Molina, C, Simonneaux, V, Pévet, P & Sassone-Corsi, P 1993, 'Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland', Nature, vol. 365, no. 6444, pp. 314-320. https://doi.org/10.1038/365314a0

Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. / Stehle, Jërg H.; Foulkes, Nicholas S.; Molina, Carlos; Simonneaux, Valérie; Pévet, Paul; Sassone-Corsi, Paolo.

In: Nature, Vol. 365, No. 6444, 01.01.1993, p. 314-320.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

AU - Stehle, Jërg H.

AU - Foulkes, Nicholas S.

AU - Molina, Carlos

AU - Simonneaux, Valérie

AU - Pévet, Paul

AU - Sassone-Corsi, Paolo

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

AB - Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

UR - http://www.scopus.com/inward/record.url?scp=0027495101&partnerID=8YFLogxK

U2 - 10.1038/365314a0

DO - 10.1038/365314a0

M3 - Article

VL - 365

SP - 314

EP - 320

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6444

ER -

Stehle JH, Foulkes NS, Molina C, Simonneaux V, Pévet P, Sassone-Corsi P. Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature. 1993 Jan 1;365(6444):314-320. https://doi.org/10.1038/365314a0