Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

Jërg H. Stehle, Nicholas S. Foulkes, Carlos Molina, Valérie Simonneaux, Paul Pévet, Paolo Sassone-Corsi

Research output: Contribution to journalArticle

342 Scopus citations

Abstract

Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalNature
Volume365
Issue number6444
DOIs
Publication statusPublished - 1 Jan 1993

    Fingerprint

Cite this

Stehle, J. H., Foulkes, N. S., Molina, C., Simonneaux, V., Pévet, P., & Sassone-Corsi, P. (1993). Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland. Nature, 365(6444), 314-320. https://doi.org/10.1038/365314a0