Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Mark T. Goulet, Derek W. Hodkey, Mary Jo Staruch, Francis J. Dumont, Shirley Lin, Shirley H.Y. Hung, John J. Siekierka, Matthew J. Wyvratt

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

Original languageEnglish
Pages (from-to)927-930
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number7
DOIs
StatePublished - 1994

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