Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Mark T. Goulet, Derek W. Hodkey, Mary Jo Staruch, Francis J. Dumont, Shirley Lin, Shirley H Y Hung, John Siekierka, Matthew J. Wyvratt

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10 Citations (Scopus)

Abstract

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

Original languageEnglish
Pages (from-to)927-930
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number7
DOIs
StatePublished - 1 Jan 1994

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Macrolides
Tacrolimus
Immunosuppressive Agents
Ether
Derivatives
Alkylation
immunomycin
trichloroacetamide
In Vitro Techniques

Cite this

Goulet, Mark T. ; Hodkey, Derek W. ; Staruch, Mary Jo ; Dumont, Francis J. ; Lin, Shirley ; Hung, Shirley H Y ; Siekierka, John ; Wyvratt, Matthew J. / Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin). In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 7. pp. 927-930.
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Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin). / Goulet, Mark T.; Hodkey, Derek W.; Staruch, Mary Jo; Dumont, Francis J.; Lin, Shirley; Hung, Shirley H Y; Siekierka, John; Wyvratt, Matthew J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 7, 01.01.1994, p. 927-930.

Research output: Contribution to journalArticleResearchpeer-review

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