Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Mark T. Goulet; Derek W. Hodkey; Mary Jo Staruch; Francis J. Dumont; Shirley Lin; Shirley H.Y. Hung; John J. Siekierka; Matthew J. Wyvratt

doi:10.1016/S0960-894X(01)80265-1

Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Mark T. Goulet
, Derek W. Hodkey
, Mary Jo Staruch
, Francis J. Dumont
, Shirley Lin
, Shirley H.Y. Hung
, John J. Siekierka
, Matthew J. Wyvratt

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

Original language	English
Pages (from-to)	927-930
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(01)80265-1
State	Published - 1994

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title = "Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)",

abstract = "Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.",

author = "Goulet, \{Mark T.\} and Hodkey, \{Derek W.\} and Staruch, \{Mary Jo\} and Dumont, \{Francis J.\} and Shirley Lin and Hung, \{Shirley H.Y.\} and Siekierka, \{John J.\} and Wyvratt, \{Matthew J.\}",

year = "1994",

doi = "10.1016/S0960-894X(01)80265-1",

language = "English",

volume = "4",

pages = "927--930",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "7",

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TY - JOUR

T1 - Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

AU - Goulet, Mark T.

AU - Hodkey, Derek W.

AU - Staruch, Mary Jo

AU - Dumont, Francis J.

AU - Lin, Shirley

AU - Hung, Shirley H.Y.

AU - Siekierka, John J.

AU - Wyvratt, Matthew J.

PY - 1994

Y1 - 1994

N2 - Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

AB - Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

UR - https://www.scopus.com/pages/publications/0028213768

U2 - 10.1016/S0960-894X(01)80265-1

DO - 10.1016/S0960-894X(01)80265-1

M3 - Article

AN - SCOPUS:0028213768

SN - 0960-894X

VL - 4

SP - 927

EP - 930

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)

Abstract

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