Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

B. Chung; P. C. Johnson; A. S. Popel

doi:10.1002/fld.1251

Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

B. Chung, P. C. Johnson, A. S. Popel

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

Original language	English
Pages (from-to)	105-128
Number of pages	24
Journal	International Journal for Numerical Methods in Fluids
Volume	53
Issue number	1
DOIs	https://doi.org/10.1002/fld.1251
State	Published - 10 Jan 2007

Keywords

Chimera grid
Depletion interaction energy
RBC aggregation
Red blood cell

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10.1002/fld.1251

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abstract = "A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.",

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AB - A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

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Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

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Keywords

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