TY - JOUR
T1 - Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma
AU - Tecklenburg, Sandra L.
AU - Mickleborough, Timothy D.
AU - Fly, Alyce D.
AU - Bai, Yeon
AU - Stager, Joel M.
PY - 2007/8
Y1 - 2007/8
N2 - Background: Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects. Objective: Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB). Methods: Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9α, 11β-prostagladin (PG)F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period. Results: The ascorbic acid diet significantly reduced (p<0.05) the maximum fall in post-exercise FEV1 (-6.4±2.4%) compared to usual (-14.3±1.6%) and placebo diet (-12.9±2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9α, 11β-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Conclusion: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.
AB - Background: Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects. Objective: Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB). Methods: Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9α, 11β-prostagladin (PG)F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period. Results: The ascorbic acid diet significantly reduced (p<0.05) the maximum fall in post-exercise FEV1 (-6.4±2.4%) compared to usual (-14.3±1.6%) and placebo diet (-12.9±2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9α, 11β-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Conclusion: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.
KW - Antioxidant
KW - Asthma
KW - Diet
KW - Exercise-induced asthma
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=34250647115&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2007.02.014
DO - 10.1016/j.rmed.2007.02.014
M3 - Article
C2 - 17412579
AN - SCOPUS:34250647115
SN - 0954-6111
VL - 101
SP - 1770
EP - 1778
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 8
ER -