Carbon disulfide reagent allows the characterization of nonpolar analytes by atmospheric pressure chemical ionization mass spectrometry

Benjamin C. Owen, Jinshan Gao, David J. Borton, Lucas M. Amundson, Enada F. Archibold, Xiaoli Tan, Khalid Azyat, Rik Tykwinski, Murray Gray, Hilkka I. Kenttämaa

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Abstract

While atmospheric pressure ionization methodologies have revolutionized the mass spectrometric analysis of nonvolatile analytes, limitations native to the chemistry of these methodologies hinder or entirely inhibit the analysis of certain analytes, specifically, many nonpolar compounds. Examination of various analytes, including asphaltene and lignin model compounds as well as saturated hydrocarbons, demonstrates that atmospheric pressure chemical ionization (APCI) using CS2 as the reagent produces an abundant and stable molecular ion (M+•) for all model compounds studied, with the exception of completely saturated aliphatic hydrocarbons and the two amino acids tested, arginine and phenylalanine. This reagent substantially broadens the applicability of mass spectrometry to nonvolatile nonpolar analytes and also facilitates the examination of radical cation chemistry by mass spectrometry.

Original languageEnglish
Pages (from-to)1924-1928
Number of pages5
JournalRapid Communications in Mass Spectrometry
Volume25
Issue number14
DOIs
StatePublished - 30 Jul 2011

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    Owen, B. C., Gao, J., Borton, D. J., Amundson, L. M., Archibold, E. F., Tan, X., Azyat, K., Tykwinski, R., Gray, M., & Kenttämaa, H. I. (2011). Carbon disulfide reagent allows the characterization of nonpolar analytes by atmospheric pressure chemical ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 25(14), 1924-1928. https://doi.org/10.1002/rcm.5063