Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice

Peter A. Hosick, Abdulhadi A. AlAmodi, Michael W. Hankins, David E. Stec

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

ABSTRACT: Chronic, low level treatment with a carbon monoxide releasing molecule (CO-RM), CORM-A1, has been shown to prevent the development of obesity in response to a high fat diet. The objective of this study was to test the hypothesis that chronic, low level treatment with this CO-RM can reverse established obesity via a mechanism independent of food intake. Dietary induced obese mice were treated with CORM-A1, the inactive compound iCORM-A1, or saline every 48 hours for 30 weeks while maintained on a high fat (60%) diet. Chronic treatment with CORM-A1 resulted in a 33% decrease from initial body weight over the 30 week treatment period while treatment with iCORM and saline were associated with 18 and 25% gain in initial body weight over the same time frame. Chronic treatment with CORM-A1 did not affect food intake or activity but resulted in a significant increase in metabolism. CORM-A1 treatment also resulted in lower fasting blood glucose, improvement in insulin sensitivity and decreased heptatic steatosis. Chronic treatment with CO releasing molecules can reverse dietary induced obesity and normalize insulin resistance independent of changes in food intake or activity. These findings are likely though a mechanism which increases metabolism.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalAdipocyte
Volume5
Issue number1
DOIs
StatePublished - 3 Feb 2016

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Keywords

  • carbon monoxide
  • diabetes
  • inflammation
  • insulin resistance
  • metabolism

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