@article{a8adcbd3cb7248ffa95abbdd3bf8804f,
title = "Cyclic sulfones from double conjugate addition of Rongalite",
abstract = "Cyclic sulfones are obtained in up to 92% yield by double conjugate addition of Rongalite (sodium hydroxymethyl sulfinate) to dienones. The major product in each case is the kinetic trans-isomer of the 3,5-disubstituted ketosulfone. Eleven examples, including aryl and alkyl substituted substrates, are reported. The advantages of the method are its experimental simplicity, tolerance for both protic and oxidation-sensitive functional groups, and sterically challenging substrates. The work also significantly expands the scope of Rongalite as a conjugate nucleophile.",
keywords = "Conjugate addition, dienones, Rongalite, sulfones",
author = "Melina Goga and Hao Zong and Jazmine Prana and Rudolph Michel and Antonia Muro and Elana Rubin and Janet Brenya and Bebbington, {Magnus W.P.}",
note = "Funding Information: We thank Montclair State University for startup funds, the NSF for an MRI grant (# 2116596, PI Dr. J. Gao, Montclair State University), and the ACS Petroleum Research Fund for additional financial support (Grant #65204-UR1). S. Finn and R. Murtada (Montclair State) are acknowledged for mass spectra as are Dr N. Dayal and Prof. H. Sintim (Purdue University). Publisher Copyright: {\textcopyright} 2023 Taylor & Francis Group, LLC.",
year = "2023",
doi = "10.1080/00397911.2023.2222316",
language = "English",
volume = "53",
pages = "1351--1359",
journal = "Synthetic Communications",
issn = "0039-7911",
publisher = "Taylor and Francis Ltd.",
number = "16",
}