Deciphering magnesium stearate thermotropic behavior

Rahul V. Haware, Bhavani Prasad Vinjamuri, Amrita Sarkar, Morgan Stefik, William C. Stagner

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Magnesium stearate (MgSt) is the most commonly used excipient for oral solid dosage forms, yet there is significant commercial physicochemical variability that can lead to variable performance of critical product attributes. Differential scanning calorimetry (DSC) is often used as a quality control tool to characterize MgSt, but little data is available regarding the physicochemical relevance for the DSC thermograms. The main aim of this study was to decipher MgSt's complex thermotropic behavior using DSC, thermogravimetric analysis, capillary melting point, polarized hot-stage microscopy, and temperature dependent small-angle X-ray scattering (SAXS) and assign physicochemical relevance to the DSC thermograms. Several DSC thermal transitions are irreversible after the first heating cycle of a heat-cool-heat-cool-heat cycle. Interestingly, after the first heat cycle, the complex cool-heat-cool-heat DSC thermograms were highly reproducible and exhibited 6 reversible exothermic-endothermic conjugate pairs. SAXS identified 5 distinct mesophases at different temperatures with Phase C′ persisting to 250 °C. MgSt maintained molecular ordering beyond 276 °C and did not undergo a simple melting phenomena reported elsewhere. This research serves as a starting point to design heat-treatment strategies to create more uniform MgSt starting material.

Original languageEnglish
Pages (from-to)314-324
Number of pages11
JournalInternational Journal of Pharmaceutics
Issue number1
StatePublished - 5 Sep 2018


  • Magnesium stearate mesophases
  • Temperature dependent small angle X-ray scattering (SAXS)
  • Thermal analysis
  • Thermotropic reversibility


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