### Abstract

The developmental outcome of 2- and 4-year-old children who had been exposed as infants to chloride-deficient formula was studied. A negative dose-response relationship was demonstrated between use of the formula without additional nutritional supplementation and cognitive outcome as measured by the Bayley Scales of Infant Development (Pearson r = -.55, P = .01) at 2 years of age. A similar negative relationship was demonstrated between this exclusive use of the defective formula and perceptual (Pearson r = -.51, P < .05), motor (Pearson r = -.52, P < .05), and fine motor (Pearson r = -.75, P < .002) ability as measured by the McCarthy Scales of Children's Abilities at 4 years of age. When other known predictors of developmental outcome were taken into account by means of multiple linear regression analyses, exclusive formula use emerged as an important predictor of the children's cognitive functioning at 2 years (model R^{2} = .59, P < .005) and of quantitative (model R^{2} = .58, P < .006), perceptual (model R^{2} = .63, P < .009), and fine motor ability (model R^{2} = .74, P < .003) at 4 years of age. These data raise concern about the developmental outcome of the children exposed to chloride-deficient formula.

Original language | English |
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Pages (from-to) | 851-857 |

Number of pages | 7 |

Journal | Pediatrics |

Volume | 79 |

Issue number | 6 |

Publication status | Published - 27 Jul 1987 |

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*Pediatrics*,

*79*(6), 851-857.