### Abstract

The developmental outcome of 2- and 4-year-old children who had been exposed as infants to chloride-deficient formula was studied. A negative dose-response relationship was demonstrated between use of the formula without additional nutritional supplementation and cognitive outcome as measured by the Bayley Scales of Infant Development (Pearson r = -.55, P = .01) at 2 years of age. A similar negative relationship was demonstrated between this exclusive use of the defective formula and perceptual (Pearson r = -.51, P < .05), motor (Pearson r = -.52, P < .05), and fine motor (Pearson r = -.75, P < .002) ability as measured by the McCarthy Scales of Children's Abilities at 4 years of age. When other known predictors of developmental outcome were taken into account by means of multiple linear regression analyses, exclusive formula use emerged as an important predictor of the children's cognitive functioning at 2 years (model R^{2} = .59, P < .005) and of quantitative (model R^{2} = .58, P < .006), perceptual (model R^{2} = .63, P < .009), and fine motor ability (model R^{2} = .74, P < .003) at 4 years of age. These data raise concern about the developmental outcome of the children exposed to chloride-deficient formula.

Original language | English |
---|---|

Pages (from-to) | 851-857 |

Number of pages | 7 |

Journal | Pediatrics |

Volume | 79 |

Issue number | 6 |

State | Published - 27 Jul 1987 |

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*Pediatrics*,

*79*(6), 851-857.

}

*Pediatrics*, vol. 79, no. 6, pp. 851-857.

**Developmental outcome in children exposed to chloride-deficient formula.** / Willoughby, A.; Moss, H. A.; Hubbard, V. S.; Bercu, B. B.; Graubard, B. I.; Vietze, Peter; Chang, C. C.; Berendes, H. W.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Developmental outcome in children exposed to chloride-deficient formula

AU - Willoughby, A.

AU - Moss, H. A.

AU - Hubbard, V. S.

AU - Bercu, B. B.

AU - Graubard, B. I.

AU - Vietze, Peter

AU - Chang, C. C.

AU - Berendes, H. W.

PY - 1987/7/27

Y1 - 1987/7/27

N2 - The developmental outcome of 2- and 4-year-old children who had been exposed as infants to chloride-deficient formula was studied. A negative dose-response relationship was demonstrated between use of the formula without additional nutritional supplementation and cognitive outcome as measured by the Bayley Scales of Infant Development (Pearson r = -.55, P = .01) at 2 years of age. A similar negative relationship was demonstrated between this exclusive use of the defective formula and perceptual (Pearson r = -.51, P < .05), motor (Pearson r = -.52, P < .05), and fine motor (Pearson r = -.75, P < .002) ability as measured by the McCarthy Scales of Children's Abilities at 4 years of age. When other known predictors of developmental outcome were taken into account by means of multiple linear regression analyses, exclusive formula use emerged as an important predictor of the children's cognitive functioning at 2 years (model R2 = .59, P < .005) and of quantitative (model R2 = .58, P < .006), perceptual (model R2 = .63, P < .009), and fine motor ability (model R2 = .74, P < .003) at 4 years of age. These data raise concern about the developmental outcome of the children exposed to chloride-deficient formula.

AB - The developmental outcome of 2- and 4-year-old children who had been exposed as infants to chloride-deficient formula was studied. A negative dose-response relationship was demonstrated between use of the formula without additional nutritional supplementation and cognitive outcome as measured by the Bayley Scales of Infant Development (Pearson r = -.55, P = .01) at 2 years of age. A similar negative relationship was demonstrated between this exclusive use of the defective formula and perceptual (Pearson r = -.51, P < .05), motor (Pearson r = -.52, P < .05), and fine motor (Pearson r = -.75, P < .002) ability as measured by the McCarthy Scales of Children's Abilities at 4 years of age. When other known predictors of developmental outcome were taken into account by means of multiple linear regression analyses, exclusive formula use emerged as an important predictor of the children's cognitive functioning at 2 years (model R2 = .59, P < .005) and of quantitative (model R2 = .58, P < .006), perceptual (model R2 = .63, P < .009), and fine motor ability (model R2 = .74, P < .003) at 4 years of age. These data raise concern about the developmental outcome of the children exposed to chloride-deficient formula.

UR - http://www.scopus.com/inward/record.url?scp=0023196427&partnerID=8YFLogxK

M3 - Article

C2 - 2438635

AN - SCOPUS:0023196427

VL - 79

SP - 851

EP - 857

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 6

ER -