Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec, Ronald M. Levy, David S. Talaga

Research output: Contribution to journalArticle

98 Scopus citations


The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

Original languageEnglish
Pages (from-to)7454-7464
Number of pages11
JournalJournal of Physical Chemistry A
Issue number38
StatePublished - 25 Sep 2003


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