Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec; Ronald M. Levy; David S. Talaga

doi:10.1021/jp035514+

Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec, Ronald M. Levy, David S. Talaga

Chemistry and Biochemistry

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118 Scopus citations

Abstract

The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

Original language	English
Pages (from-to)	7454-7464
Number of pages	11
Journal	Journal of Physical Chemistry A
Volume	107
Issue number	38
DOIs	https://doi.org/10.1021/jp035514+
State	Published - 25 Sep 2003

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title = "Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models",

abstract = "The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.",

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AU - Talaga, David S.

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N2 - The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

AB - The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

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EP - 7464

JO - Journal of Physical Chemistry A

JF - Journal of Physical Chemistry A

IS - 38

ER -

Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

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