Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec, Ronald M. Levy, David S. Talaga

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

Original languageEnglish
Pages (from-to)7454-7464
Number of pages11
JournalJournal of Physical Chemistry A
Volume107
Issue number38
DOIs
StatePublished - 25 Sep 2003

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Hidden Markov models
arrivals
Photons
Trajectories
trajectories
Molecules
Kinetics
kinetics
photons
molecules
Data storage equipment
Wavelength
wavelengths
Experiments

Cite this

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abstract = "The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.",
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Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models. / Andrec, Michael; Levy, Ronald M.; Talaga, David S.

In: Journal of Physical Chemistry A, Vol. 107, No. 38, 25.09.2003, p. 7454-7464.

Research output: Contribution to journalArticle

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