Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec; Ronald M. Levy; David S. Talaga

doi:10.1021/jp035514+

Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

Michael Andrec, Ronald M. Levy, David S. Talaga

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

Original language	English
Pages (from-to)	7454-7464
Number of pages	11
Journal	Journal of Physical Chemistry A
Volume	107
Issue number	38
DOIs	https://doi.org/10.1021/jp035514+
State	Published - 25 Sep 2003

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@article{93e479f9dc034d88a6807bd96fb3bb52,

title = "Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models",

abstract = "The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.",

author = "Michael Andrec and Levy, \{Ronald M.\} and Talaga, \{David S.\}",

year = "2003",

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doi = "10.1021/jp035514+",

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T1 - Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

AU - Andrec, Michael

AU - Levy, Ronald M.

AU - Talaga, David S.

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Y1 - 2003/9/25

N2 - The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

AB - The kinetic rates of single-molecule photon trajectories were determined using hidden Markov model (HMM). The data from single-molecule experiments were in the form of photon trajectories consisting of arrival times and wavelength information on individual photons. HMM was used as an alternative to higher-order correlation function analysis for the detection of conformational memory.

UR - https://www.scopus.com/pages/publications/0141959728

U2 - 10.1021/jp035514+

DO - 10.1021/jp035514+

M3 - Article

AN - SCOPUS:0141959728

SN - 1089-5639

VL - 107

SP - 7454

EP - 7464

JO - Journal of Physical Chemistry A

JF - Journal of Physical Chemistry A

IS - 38

ER -

Direct Determination of Kinetic Rates from Single-Molecule Photon Arrival Trajectories Using Hidden Markov Models

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