Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

David Rotella, E. K. Bayburt, M. P. Capparelli, B. J. Carroll, R. Goldstein, M. R. Justice, L. Zhu, S. Hu, R. A. Melton, L. Freyer, R. L. Golding, J. R. Doughty, S. Spirito, V. Bloncuzzi, D. Wilson, E. M. Byrne, V. Ganu, D. T. Parker

Research output: Contribution to journalComment/debateResearch

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalChemtracts
Volume11
Issue number4
StatePublished - 1 Apr 1998

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Matrix Metalloproteinase Inhibitors
Cartilage
Rabbits
CGS 27023A

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Rotella, D., Bayburt, E. K., Capparelli, M. P., Carroll, B. J., Goldstein, R., Justice, M. R., ... Parker, D. T. (1998). Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. Chemtracts, 11(4), 301-305.
Rotella, David ; Bayburt, E. K. ; Capparelli, M. P. ; Carroll, B. J. ; Goldstein, R. ; Justice, M. R. ; Zhu, L. ; Hu, S. ; Melton, R. A. ; Freyer, L. ; Golding, R. L. ; Doughty, J. R. ; Spirito, S. ; Bloncuzzi, V. ; Wilson, D. ; Byrne, E. M. ; Ganu, V. ; Parker, D. T. / Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. In: Chemtracts. 1998 ; Vol. 11, No. 4. pp. 301-305.
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author = "David Rotella and Bayburt, {E. K.} and Capparelli, {M. P.} and Carroll, {B. J.} and R. Goldstein and Justice, {M. R.} and L. Zhu and S. Hu and Melton, {R. A.} and L. Freyer and Golding, {R. L.} and Doughty, {J. R.} and S. Spirito and V. Bloncuzzi and D. Wilson and Byrne, {E. M.} and V. Ganu and Parker, {D. T.}",
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Rotella, D, Bayburt, EK, Capparelli, MP, Carroll, BJ, Goldstein, R, Justice, MR, Zhu, L, Hu, S, Melton, RA, Freyer, L, Golding, RL, Doughty, JR, Spirito, S, Bloncuzzi, V, Wilson, D, Byrne, EM, Ganu, V & Parker, DT 1998, 'Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits', Chemtracts, vol. 11, no. 4, pp. 301-305.

Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. / Rotella, David; Bayburt, E. K.; Capparelli, M. P.; Carroll, B. J.; Goldstein, R.; Justice, M. R.; Zhu, L.; Hu, S.; Melton, R. A.; Freyer, L.; Golding, R. L.; Doughty, J. R.; Spirito, S.; Bloncuzzi, V.; Wilson, D.; Byrne, E. M.; Ganu, V.; Parker, D. T.

In: Chemtracts, Vol. 11, No. 4, 01.04.1998, p. 301-305.

Research output: Contribution to journalComment/debateResearch

TY - JOUR

T1 - Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

AU - Rotella, David

AU - Bayburt, E. K.

AU - Capparelli, M. P.

AU - Carroll, B. J.

AU - Goldstein, R.

AU - Justice, M. R.

AU - Zhu, L.

AU - Hu, S.

AU - Melton, R. A.

AU - Freyer, L.

AU - Golding, R. L.

AU - Doughty, J. R.

AU - Spirito, S.

AU - Bloncuzzi, V.

AU - Wilson, D.

AU - Byrne, E. M.

AU - Ganu, V.

AU - Parker, D. T.

PY - 1998/4/1

Y1 - 1998/4/1

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M3 - Comment/debate

VL - 11

SP - 301

EP - 305

JO - Chemtracts

JF - Chemtracts

SN - 1431-9268

IS - 4

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Rotella D, Bayburt EK, Capparelli MP, Carroll BJ, Goldstein R, Justice MR et al. Discovery of CGS 27023A, a nonpeptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. Chemtracts. 1998 Apr 1;11(4):301-305.