Disinhibition of prefrontal cortex neurons in schizophrenia

B. Moghaddam, Alan Pehrson

Research output: Chapter in Book/Report/Conference proceedingChapter


A large body of evidence has implicated abnormal functioning of the prefrontal cortex (PFC) in the pathophysiology of schizophrenia (Robbins 1996; Andreasen et al. 1997; Winterer and Wvneinberger 2004; Lewis and Moghaddam 2006). These abnormalities are found at molecular and functional levels and are thought to be the basis of cognitive deficits in individuals with schizophrenia. However, little is known about the physiological mechanisms that contribute to this malfunction. Here we review some of the literature that points to PFC abnormalities in schizophrenia and recent theories that unify the multimodal functional and postmortem findings in schizophrenia.

Original languageEnglish
Title of host publicationAdvances in Schizophrenia Research 2009
PublisherSpringer New York
Number of pages13
ISBN (Print)9781441909121
Publication statusPublished - 1 Dec 2010


Cite this

Moghaddam, B., & Pehrson, A. (2010). Disinhibition of prefrontal cortex neurons in schizophrenia. In Advances in Schizophrenia Research 2009 (pp. 99-111). Springer New York. https://doi.org/10.1007/978-1-4419-0913-8_5