Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions

Keyphrases

• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Ligand Interaction 100%
• Protein Motion 60%
• Ligand Binding 60%
• Amino Acids 40%
• Distal mutation 40%
• Active Sites 20%
• Catalytic Cycle 20%
• Enzyme Catalysis 20%
• Enzyme Inhibitors 20%
• Hydride Transfer 20%
• Dihydrofolate 20%
• Protein-ligand Interaction 20%
• Computational Methods 20%
• Protein Function 20%
• Kinetic Measurements 20%
• Model Enzyme 20%
• Transfer Rate 20%
• Protein Analysis 20%
• Protein Dynamics 20%
• Enzyme Mechanism 20%
• Tetrahydrofolate 20%
• Catalytic Efficacy 20%
• Essential Enzymes 20%
• Enzyme Kinetics 20%

Biochemistry, Genetics and Molecular Biology

• Dihydrofolate Reductase 100%
• Motion 100%
• Ligand Binding 60%
• Amino Acids 40%
• Active Site 20%
• Enzyme 20%
• Enzyme Catalysis 20%
• Enzyme Inhibitor 20%
• Enzyme Models 20%
• Enzyme Mechanism 20%
• Enzyme Kinetics 20%
• Protein Dynamics 20%
• Tetrahydrofolic Acid 20%
• Protein-Ligand Interaction 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Dihydrofolate Reductase 100%
• Amino Acid 40%
• Enzyme Inhibitor 20%
• Dihydrofolic Acid 20%
• Enzyme Kinetics 20%
• Protein Ligand 20%
• Tetrahydrofolic Acid 20%