Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Christian A. Kell, Faramarz Dehghani, Helmut Wicht, Carlos Molina, Horst Werner Korf, Jörg H. Stehle

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In morphogenetic dynamics of neurons, and in adaptive physiology of brain function, transcription factors of the cyclicAMP signaling pathway, such as activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role. In particular, the presence of the transcription factor ICER in neurons or neuroendocrine cells suggests the need for the gating of an up-regulated gene expression. Little is known, however, about the natural distribution of the inhibitory transcription factor ICER. We, therefore, mapped the rodent brain and pituitary for an ICER immunoreaction and found a nuclear staining for this transcription factor. ICER-positive glial cells were found throughout the brain. ICER-positive neurons were found in sensory input centers, like the olfactory bulb, or sensory brain stem nuclei, and in hypothalamic nuclei involved in central neuroendocrine control. In addition, neuroendocrine/endocrine transducers, like the pituitary and the pineal gland showed a high basal presence of ICER. Our data show that a basic ICER level is required by many cell systems and can be seen as an anticipatory and/or a protective measure in systems with superior reactive dynamics.

Original languageEnglish
Pages (from-to)379-394
Number of pages16
JournalJournal of Comparative Neurology
Volume478
Issue number4
DOIs
StatePublished - 25 Oct 2004

Fingerprint

Rodentia
Transcription Factors
Brain
Neurons
Neuroendocrine Cells
Pineal Gland
Olfactory Bulb
Pituitary Gland
Transducers
Neuroglia
Brain Stem
Carrier Proteins
Staining and Labeling
Gene Expression

Keywords

  • C3H
  • C57BL
  • Mouse
  • Pars tuberalis
  • Rat
  • Tyrosine hydroxylase

Cite this

Kell, Christian A. ; Dehghani, Faramarz ; Wicht, Helmut ; Molina, Carlos ; Korf, Horst Werner ; Stehle, Jörg H. / Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. In: Journal of Comparative Neurology. 2004 ; Vol. 478, No. 4. pp. 379-394.
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Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. / Kell, Christian A.; Dehghani, Faramarz; Wicht, Helmut; Molina, Carlos; Korf, Horst Werner; Stehle, Jörg H.

In: Journal of Comparative Neurology, Vol. 478, No. 4, 25.10.2004, p. 379-394.

Research output: Contribution to journalArticle

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T1 - Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

AU - Kell, Christian A.

AU - Dehghani, Faramarz

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AU - Korf, Horst Werner

AU - Stehle, Jörg H.

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