Do incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?

Mousumi Bose, Blanca Oliván, Julio Teixeira, F. Xavier Pi-Sunyer, Blandine Laferrère

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 diabetes (T2DM). The mechanisms by which this remission occurs are unclear. Besides weight loss and caloric restriction, the changes in gut hormones that occur after GBP are increasingly gaining recognition as key players in glucose control. Incretins are gut peptides that stimulate insulin secretion postprandially; the levels of these hormones, particularly glucagon-like peptide-1, increase after GBP in response to nutrient stimulation. Whether these changes are causal to changes in glucose homeostasis remain to be determined. The purpose of this review is to assess the evidence on incretin changes and T2DM remission after GBP, and the possible mechanisms by which these changes occur. Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated.

Original languageEnglish
Pages (from-to)217-229
Number of pages13
JournalObesity Surgery
Volume19
Issue number2
DOIs
StatePublished - 1 Feb 2009

Keywords

  • Diabetes
  • GIP
  • GLP-1
  • Gastric bypass
  • Incretin
  • Insulin
  • Weight loss

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