Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels

Blanca Oliván, Julio Teixeira, Mousumi Bose, Baani Bawa, Tangel Chang, Heather Summe, Hongchan Lee, Blandine Laferrère

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Abstract

Objective: To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels. SUMMARY BACKGROUND DATA:: The increased PYY3-36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery. METHODS:: Of the 30 morbidly obese women who participated in the study, 21 had type 2 diabetes mellitus, and were studied before and after equivalent weight loss of 10 kg by either GBP (n = 11) or by diet (n = 10). RESULTS:: PYY3-36 levels were higher in obese diabetic as compared with nondiabetic individuals (64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL; P < 0.05). PYY3-36 levels increased markedly in response to oral glucose after GBP (peak: 72.3 ± 20.5 pg/mL-132.7 ± 49.7 pg/mL; P < 0.001; AUC0-180: 51.5 ± 23.3 pg/mL.min-91.1 ± 32.2 pg/mL.min P < 0.001), but not after diet (peak: 85.5 ± 51.9 pg/mL-84.8 ± 41.13 pg/mL; P = NS; AUC0-180: 68.3 ± 38.5 pg/mL.min-61.1 ± 42.2 pg/mL.min P = NS). Fasting ghrelin levels increased after diet (425 ± 91 pg/mL-519 ± 105 pg/mL; P < 0.05), but did not change after GBP (506 ± 121 pg/mL-482 ± 196 pg/mL; P = NS). CONCLUSIONS:: Diabetes status seems to be a determinant of PYY3-36 levels. GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3-36 levels. The increase in stimulated PYY3-36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss. Changes in PYY3-36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss.

Original languageEnglish
Pages (from-to)948-953
Number of pages6
JournalAnnals of Surgery
Volume249
Issue number6
DOIs
StatePublished - 1 Jun 2009

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Reducing Diet
Gastric Bypass
Weight Loss
Ghrelin
Diet
peptide YY (3-36)
Glucose
Leptin
Type 2 Diabetes Mellitus
Fasting

Cite this

Oliván, B., Teixeira, J., Bose, M., Bawa, B., Chang, T., Summe, H., ... Laferrère, B. (2009). Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. Annals of Surgery, 249(6), 948-953. https://doi.org/10.1097/SLA.0b013e3181a6cdb0
Oliván, Blanca ; Teixeira, Julio ; Bose, Mousumi ; Bawa, Baani ; Chang, Tangel ; Summe, Heather ; Lee, Hongchan ; Laferrère, Blandine. / Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. In: Annals of Surgery. 2009 ; Vol. 249, No. 6. pp. 948-953.
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abstract = "Objective: To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels. SUMMARY BACKGROUND DATA:: The increased PYY3-36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery. METHODS:: Of the 30 morbidly obese women who participated in the study, 21 had type 2 diabetes mellitus, and were studied before and after equivalent weight loss of 10 kg by either GBP (n = 11) or by diet (n = 10). RESULTS:: PYY3-36 levels were higher in obese diabetic as compared with nondiabetic individuals (64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL; P < 0.05). PYY3-36 levels increased markedly in response to oral glucose after GBP (peak: 72.3 ± 20.5 pg/mL-132.7 ± 49.7 pg/mL; P < 0.001; AUC0-180: 51.5 ± 23.3 pg/mL.min-91.1 ± 32.2 pg/mL.min P < 0.001), but not after diet (peak: 85.5 ± 51.9 pg/mL-84.8 ± 41.13 pg/mL; P = NS; AUC0-180: 68.3 ± 38.5 pg/mL.min-61.1 ± 42.2 pg/mL.min P = NS). Fasting ghrelin levels increased after diet (425 ± 91 pg/mL-519 ± 105 pg/mL; P < 0.05), but did not change after GBP (506 ± 121 pg/mL-482 ± 196 pg/mL; P = NS). CONCLUSIONS:: Diabetes status seems to be a determinant of PYY3-36 levels. GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3-36 levels. The increase in stimulated PYY3-36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss. Changes in PYY3-36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss.",
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Oliván, B, Teixeira, J, Bose, M, Bawa, B, Chang, T, Summe, H, Lee, H & Laferrère, B 2009, 'Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels', Annals of Surgery, vol. 249, no. 6, pp. 948-953. https://doi.org/10.1097/SLA.0b013e3181a6cdb0

Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. / Oliván, Blanca; Teixeira, Julio; Bose, Mousumi; Bawa, Baani; Chang, Tangel; Summe, Heather; Lee, Hongchan; Laferrère, Blandine.

In: Annals of Surgery, Vol. 249, No. 6, 01.06.2009, p. 948-953.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels

AU - Oliván, Blanca

AU - Teixeira, Julio

AU - Bose, Mousumi

AU - Bawa, Baani

AU - Chang, Tangel

AU - Summe, Heather

AU - Lee, Hongchan

AU - Laferrère, Blandine

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Objective: To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels. SUMMARY BACKGROUND DATA:: The increased PYY3-36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery. METHODS:: Of the 30 morbidly obese women who participated in the study, 21 had type 2 diabetes mellitus, and were studied before and after equivalent weight loss of 10 kg by either GBP (n = 11) or by diet (n = 10). RESULTS:: PYY3-36 levels were higher in obese diabetic as compared with nondiabetic individuals (64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL; P < 0.05). PYY3-36 levels increased markedly in response to oral glucose after GBP (peak: 72.3 ± 20.5 pg/mL-132.7 ± 49.7 pg/mL; P < 0.001; AUC0-180: 51.5 ± 23.3 pg/mL.min-91.1 ± 32.2 pg/mL.min P < 0.001), but not after diet (peak: 85.5 ± 51.9 pg/mL-84.8 ± 41.13 pg/mL; P = NS; AUC0-180: 68.3 ± 38.5 pg/mL.min-61.1 ± 42.2 pg/mL.min P = NS). Fasting ghrelin levels increased after diet (425 ± 91 pg/mL-519 ± 105 pg/mL; P < 0.05), but did not change after GBP (506 ± 121 pg/mL-482 ± 196 pg/mL; P = NS). CONCLUSIONS:: Diabetes status seems to be a determinant of PYY3-36 levels. GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3-36 levels. The increase in stimulated PYY3-36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss. Changes in PYY3-36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss.

AB - Objective: To examine the effect of an equivalent weight loss, by gastric bypass surgery (GBP) or by diet, on peptide YY3-36 (PYY3-36), ghrelin, and leptin levels and to determine the effect of diabetes status on PYY3-36 levels. SUMMARY BACKGROUND DATA:: The increased PYY3-36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery. METHODS:: Of the 30 morbidly obese women who participated in the study, 21 had type 2 diabetes mellitus, and were studied before and after equivalent weight loss of 10 kg by either GBP (n = 11) or by diet (n = 10). RESULTS:: PYY3-36 levels were higher in obese diabetic as compared with nondiabetic individuals (64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL; P < 0.05). PYY3-36 levels increased markedly in response to oral glucose after GBP (peak: 72.3 ± 20.5 pg/mL-132.7 ± 49.7 pg/mL; P < 0.001; AUC0-180: 51.5 ± 23.3 pg/mL.min-91.1 ± 32.2 pg/mL.min P < 0.001), but not after diet (peak: 85.5 ± 51.9 pg/mL-84.8 ± 41.13 pg/mL; P = NS; AUC0-180: 68.3 ± 38.5 pg/mL.min-61.1 ± 42.2 pg/mL.min P = NS). Fasting ghrelin levels increased after diet (425 ± 91 pg/mL-519 ± 105 pg/mL; P < 0.05), but did not change after GBP (506 ± 121 pg/mL-482 ± 196 pg/mL; P = NS). CONCLUSIONS:: Diabetes status seems to be a determinant of PYY3-36 levels. GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3-36 levels. The increase in stimulated PYY3-36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss. Changes in PYY3-36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss.

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