Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats

Keyphrases

• Female Rats 100%
• Vortioxetine 100%
• Glutamatergic Activity 100%
• Depression Model 100%
• Paroxetine 70%
• Tryptophan Depletion 60%
• Tryptophan 30%
• Aldosterone 30%
• Antidepressants 20%
• Serotonin Transporter 20%
• Depressive-like Behavior 20%
• Drinking Water 10%
• Sprague-Dawley Rats 10%
• Corticosterone 10%
• Interleukin-6 10%
• Hippocampus 10%
• Amygdala 10%
• Receptor Expression 10%
• Transporter Inhibition 10%
• Glutamate Neurotransmission 10%
• Female Rat Model 10%
• IL-6 Level 10%
• Plasma Corticosterone 10%
• Kynurenic Acid 10%
• Indirect Indicators 10%
• N-methyl-D-aspartate 10%
• Potential Biomarkers 10%
• Nicotinic Acetylcholine Receptor (nAChR) 10%

Neuroscience

• Selective Serotonin Reuptake Inhibitor 100%
• Female Rats 100%
• Vortioxetine 100%
• Tryptophan 90%
• Paroxetine 70%
• Aldosterone 30%
• Behavior (Neuroscience) 20%
• Antidepressant 20%
• Serotonin Transporter 20%
• Corticosterone 20%
• Neurotransmission 10%
• Glutamic Acid 10%
• Hippocampus 10%
• Amygdala 10%
• Receptor Expression 10%
• Kynurenic Acid 10%
• Aspartic Acid 10%
• Nicotinic Acetylcholine Receptor 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Selective Serotonin Reuptake Inhibitor 100%
• Biological Marker 100%
• Vortioxetine 100%
• Tryptophan 90%
• Paroxetine 70%
• Aldosterone 30%
• Serotonin Transporter 20%
• Corticosterone 20%
• Antidepressant Activity 20%
• Sprague Dawley Rat 10%
• Glutamic Acid 10%
• Rat Model 10%
• Kynurenic Acid 10%
• Aspartic Acid 10%
• Nicotinic Receptor 10%