Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users

Akinori Kashio, Viral D. Tejani, Rachel Scheperle, Carolyn J. Brown, Paul J. Abbas

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intracochlear locations. For most individuals, N1 latency was similar across recording electrodes. However, reduced N1 latencies were observed in 21% of cochlear implant users when ECAPs were recorded using a remote recording electrode. We hypothesized that if recordings from different electrodes represented contributions from different populations of neurons, then one might expect that channel interaction functions would be different. However, we did not observe consistent differences in channel interaction functions (neither peak location nor breadth of the functions), and further, any variation in channel interaction functions was not correlated with ECAP latency. These results suggest that ECAPs from different recording electrodes with different latencies originate from similar neural populations.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalAudiology and Neurotology
Volume21
Issue number3
DOIs
StatePublished - 1 Jul 2016

Fingerprint

Cochlear Implants
Reaction Time
Electrodes
Action Potentials
Population
Cochlea
Neurons

Keywords

  • Auditory evoked potentials
  • Auditory system
  • Cochlear implant
  • Compound action potential
  • Electrically evoked potential

Cite this

Kashio, Akinori ; Tejani, Viral D. ; Scheperle, Rachel ; Brown, Carolyn J. ; Abbas, Paul J. / Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users. In: Audiology and Neurotology. 2016 ; Vol. 21, No. 3. pp. 141-149.
@article{4b759bbd67a84c9989f1eda199b18dd8,
title = "Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users",
abstract = "In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intracochlear locations. For most individuals, N1 latency was similar across recording electrodes. However, reduced N1 latencies were observed in 21{\%} of cochlear implant users when ECAPs were recorded using a remote recording electrode. We hypothesized that if recordings from different electrodes represented contributions from different populations of neurons, then one might expect that channel interaction functions would be different. However, we did not observe consistent differences in channel interaction functions (neither peak location nor breadth of the functions), and further, any variation in channel interaction functions was not correlated with ECAP latency. These results suggest that ECAPs from different recording electrodes with different latencies originate from similar neural populations.",
keywords = "Auditory evoked potentials, Auditory system, Cochlear implant, Compound action potential, Electrically evoked potential",
author = "Akinori Kashio and Tejani, {Viral D.} and Rachel Scheperle and Brown, {Carolyn J.} and Abbas, {Paul J.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1159/000444739",
language = "English",
volume = "21",
pages = "141--149",
journal = "Audiology and Neurotology",
issn = "1420-3030",
publisher = "S. Karger AG",
number = "3",

}

Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users. / Kashio, Akinori; Tejani, Viral D.; Scheperle, Rachel; Brown, Carolyn J.; Abbas, Paul J.

In: Audiology and Neurotology, Vol. 21, No. 3, 01.07.2016, p. 141-149.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users

AU - Kashio, Akinori

AU - Tejani, Viral D.

AU - Scheperle, Rachel

AU - Brown, Carolyn J.

AU - Abbas, Paul J.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intracochlear locations. For most individuals, N1 latency was similar across recording electrodes. However, reduced N1 latencies were observed in 21% of cochlear implant users when ECAPs were recorded using a remote recording electrode. We hypothesized that if recordings from different electrodes represented contributions from different populations of neurons, then one might expect that channel interaction functions would be different. However, we did not observe consistent differences in channel interaction functions (neither peak location nor breadth of the functions), and further, any variation in channel interaction functions was not correlated with ECAP latency. These results suggest that ECAPs from different recording electrodes with different latencies originate from similar neural populations.

AB - In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intracochlear locations. For most individuals, N1 latency was similar across recording electrodes. However, reduced N1 latencies were observed in 21% of cochlear implant users when ECAPs were recorded using a remote recording electrode. We hypothesized that if recordings from different electrodes represented contributions from different populations of neurons, then one might expect that channel interaction functions would be different. However, we did not observe consistent differences in channel interaction functions (neither peak location nor breadth of the functions), and further, any variation in channel interaction functions was not correlated with ECAP latency. These results suggest that ECAPs from different recording electrodes with different latencies originate from similar neural populations.

KW - Auditory evoked potentials

KW - Auditory system

KW - Cochlear implant

KW - Compound action potential

KW - Electrically evoked potential

UR - http://www.scopus.com/inward/record.url?scp=84979608087&partnerID=8YFLogxK

U2 - 10.1159/000444739

DO - 10.1159/000444739

M3 - Article

VL - 21

SP - 141

EP - 149

JO - Audiology and Neurotology

JF - Audiology and Neurotology

SN - 1420-3030

IS - 3

ER -