FK-506 and cyclosporin A

immunosuppressive mechanism of action and beyond

John Siekierka, Nolan H. Sigal

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Abstract

Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions, led to the identification of two new gene families whose products may function as components of several diverse signal transduction pathways. In the presence of the immunosuppressive drugs, some members of the receptor families interact with the Ca2+/calmodulin-dependent protein phosphatase 2B, also known as calcineurin. Inhibition of phosphatase activity may effect several downstream biochemical processes. In this way, cyclosporin A and FK-506 have proved to be useful probes of signaling events in both lymphocytic and other cell types.

Original languageEnglish
Pages (from-to)548-552
Number of pages5
JournalCurrent Opinion in Immunology
Volume4
Issue number5
DOIs
StatePublished - 1 Jan 1992

Fingerprint

Calcineurin
Tacrolimus
Immunosuppressive Agents
Cyclosporine
Biochemical Phenomena
Tissue Transplantation
Graft Rejection
Calmodulin
Phosphoric Monoester Hydrolases
Pharmaceutical Preparations
Signal Transduction
Research
Genes
Therapeutics
Inhibition (Psychology)

Cite this

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FK-506 and cyclosporin A : immunosuppressive mechanism of action and beyond. / Siekierka, John; Sigal, Nolan H.

In: Current Opinion in Immunology, Vol. 4, No. 5, 01.01.1992, p. 548-552.

Research output: Contribution to journalArticleResearchpeer-review

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