Food group intake and risk of subtypes of esophageal and gastric cancer

Stephanie A. Navarro Silvera, Susan T. Mayne, Harvey Risch, Marilee D. Gammon, Thomas L. Vaughan, Wong Ho Chow, Robert Dubrow, Janet B. Schoenberg, Janet L. Stanford, A. Brian West, Heidrun Rotterdam, William J. Blot, Joseph F. Fraumeni

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.

Original languageEnglish
Pages (from-to)852-860
Number of pages9
JournalInternational Journal of Cancer
Volume123
Issue number4
DOIs
StatePublished - 15 Aug 2008

Fingerprint

Esophageal Neoplasms
Stomach Neoplasms
Adenocarcinoma
Eating
Odds Ratio
Stomach
Cardia
Meat
Poultry
Vegetables
Fats
Case-Control Studies
Food

Keywords

  • Case-control
  • Esophageal neoplasms
  • Food groups
  • Gastric neoplasms

Cite this

Navarro Silvera, S. A., Mayne, S. T., Risch, H., Gammon, M. D., Vaughan, T. L., Chow, W. H., ... Fraumeni, J. F. (2008). Food group intake and risk of subtypes of esophageal and gastric cancer. International Journal of Cancer, 123(4), 852-860. https://doi.org/10.1002/ijc.23544
Navarro Silvera, Stephanie A. ; Mayne, Susan T. ; Risch, Harvey ; Gammon, Marilee D. ; Vaughan, Thomas L. ; Chow, Wong Ho ; Dubrow, Robert ; Schoenberg, Janet B. ; Stanford, Janet L. ; West, A. Brian ; Rotterdam, Heidrun ; Blot, William J. ; Fraumeni, Joseph F. / Food group intake and risk of subtypes of esophageal and gastric cancer. In: International Journal of Cancer. 2008 ; Vol. 123, No. 4. pp. 852-860.
@article{75f146c57a544ee18ed79c83f101d5b7,
title = "Food group intake and risk of subtypes of esophageal and gastric cancer",
abstract = "Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95{\%} CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95{\%} CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95{\%} CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95{\%} CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95{\%} CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95{\%} CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95{\%} CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.",
keywords = "Case-control, Esophageal neoplasms, Food groups, Gastric neoplasms",
author = "{Navarro Silvera}, {Stephanie A.} and Mayne, {Susan T.} and Harvey Risch and Gammon, {Marilee D.} and Vaughan, {Thomas L.} and Chow, {Wong Ho} and Robert Dubrow and Schoenberg, {Janet B.} and Stanford, {Janet L.} and West, {A. Brian} and Heidrun Rotterdam and Blot, {William J.} and Fraumeni, {Joseph F.}",
year = "2008",
month = "8",
day = "15",
doi = "10.1002/ijc.23544",
language = "English",
volume = "123",
pages = "852--860",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

Navarro Silvera, SA, Mayne, ST, Risch, H, Gammon, MD, Vaughan, TL, Chow, WH, Dubrow, R, Schoenberg, JB, Stanford, JL, West, AB, Rotterdam, H, Blot, WJ & Fraumeni, JF 2008, 'Food group intake and risk of subtypes of esophageal and gastric cancer', International Journal of Cancer, vol. 123, no. 4, pp. 852-860. https://doi.org/10.1002/ijc.23544

Food group intake and risk of subtypes of esophageal and gastric cancer. / Navarro Silvera, Stephanie A.; Mayne, Susan T.; Risch, Harvey; Gammon, Marilee D.; Vaughan, Thomas L.; Chow, Wong Ho; Dubrow, Robert; Schoenberg, Janet B.; Stanford, Janet L.; West, A. Brian; Rotterdam, Heidrun; Blot, William J.; Fraumeni, Joseph F.

In: International Journal of Cancer, Vol. 123, No. 4, 15.08.2008, p. 852-860.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Food group intake and risk of subtypes of esophageal and gastric cancer

AU - Navarro Silvera, Stephanie A.

AU - Mayne, Susan T.

AU - Risch, Harvey

AU - Gammon, Marilee D.

AU - Vaughan, Thomas L.

AU - Chow, Wong Ho

AU - Dubrow, Robert

AU - Schoenberg, Janet B.

AU - Stanford, Janet L.

AU - West, A. Brian

AU - Rotterdam, Heidrun

AU - Blot, William J.

AU - Fraumeni, Joseph F.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.

AB - Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.

KW - Case-control

KW - Esophageal neoplasms

KW - Food groups

KW - Gastric neoplasms

UR - http://www.scopus.com/inward/record.url?scp=47049094562&partnerID=8YFLogxK

U2 - 10.1002/ijc.23544

DO - 10.1002/ijc.23544

M3 - Article

C2 - 18537156

AN - SCOPUS:47049094562

VL - 123

SP - 852

EP - 860

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -