Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems

Dominic Roberts, Andrew Wolfarth, Connie Sanchez, Alan L. Pehrson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we develop a model of μ- and δ-opioid receptor (OR) effects on cellular activity in the corticostriatal circuit after reviewing clinical data on cognitive and mood impairments in opioid substance use disorder (OUD), we use this model to derive information on the relevance of opioid actions in this circuit for cognition and reward. We find that the cognitive impairments and rewarding properties of acute μ-OR activation can reasonably explained by pharmacological actions in the corticostriatal circuit. However, long-term cognitive impairments and mood dysfunction observed in OUD are probably induced by opiate abuse-related degenerative mechanisms.

Original languageEnglish
Title of host publicationProgress in Brain Research
EditorsShane O'Mara
PublisherElsevier B.V.
Pages179-227
Number of pages49
ISBN (Print)9780444641670
DOIs
StatePublished - 1 Jan 2018

Publication series

NameProgress in Brain Research
Volume239
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Cognition
  • Frontal cortex
  • Mood
  • Nucleus accumbens
  • Opioid substance use disorder
  • δ-Opioid receptor
  • μ-Opioid receptor

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    Roberts, D., Wolfarth, A., Sanchez, C., & Pehrson, A. L. (2018). Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems. In S. O'Mara (Ed.), Progress in Brain Research (pp. 179-227). (Progress in Brain Research; Vol. 239). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2018.07.001