Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam; B. J. Van Der Schueren; B. Ahren; G. C. Wang; N. J. Swerdlow; S. Arias; M. Bose; P. Gorroochurn; J. Teixeira; J. McGinty; B. Laferrère

doi:10.1111/j.1463-1326.2011.01358.x

Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam, B. J. Van Der Schueren, B. Ahren, G. C. Wang, N. J. Swerdlow, S. Arias, M. Bose, P. Gorroochurn, J. Teixeira, J. McGinty, B. Laferrère

Nutrition and Food Studies

Research output: Contribution to journal › Letter › peer-review

32 Scopus citations

Abstract

The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

Original language	English
Pages (from-to)	378-381
Number of pages	4
Journal	Diabetes, Obesity and Metabolism
Volume	13
Issue number	4
DOIs	https://doi.org/10.1111/j.1463-1326.2011.01358.x
State	Published - Apr 2011

Keywords

Dipeptidyl peptidase inhibitor
GLP-1
Gastric bypass
Weight loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1463-1326.2011.01358.x

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Alam, M. L., Van Der Schueren, B. J., Ahren, B., Wang, G. C., Swerdlow, N. J., Arias, S., Bose, M., Gorroochurn, P., Teixeira, J., McGinty, J., & Laferrère, B. (2011). Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 13(4), 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x

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abstract = "The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.",

keywords = "Dipeptidyl peptidase inhibitor, GLP-1, Gastric bypass, Weight loss",

author = "Alam, {M. L.} and {Van Der Schueren}, {B. J.} and B. Ahren and Wang, {G. C.} and Swerdlow, {N. J.} and S. Arias and M. Bose and P. Gorroochurn and J. Teixeira and J. McGinty and B. Laferr{\`e}re",

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Alam, ML, Van Der Schueren, BJ, Ahren, B, Wang, GC, Swerdlow, NJ, Arias, S, Bose, M, Gorroochurn, P, Teixeira, J, McGinty, J & Laferrère, B 2011, 'Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes', Diabetes, Obesity and Metabolism, vol. 13, no. 4, pp. 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x

TY - JOUR

T1 - Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

AU - Alam, M. L.

AU - Van Der Schueren, B. J.

AU - Ahren, B.

AU - Wang, G. C.

AU - Swerdlow, N. J.

AU - Arias, S.

AU - Bose, M.

AU - Gorroochurn, P.

AU - Teixeira, J.

AU - McGinty, J.

AU - Laferrère, B.

PY - 2011/4

Y1 - 2011/4

N2 - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

AB - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

KW - Dipeptidyl peptidase inhibitor

KW - GLP-1

KW - Gastric bypass

KW - Weight loss

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Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

Abstract

Keywords

UN SDGs

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