Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam, B. J. Van Der Schueren, B. Ahren, G. C. Wang, N. J. Swerdlow, S. Arias, M. Bose, P. Gorroochurn, J. Teixeira, J. McGinty, B. Laferrère

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Abstract

The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalDiabetes, Obesity and Metabolism
Volume13
Issue number4
DOIs
StatePublished - 1 Jan 2011

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Keywords

  • Dipeptidyl peptidase inhibitor
  • GLP-1
  • Gastric bypass
  • Weight loss

Cite this

Alam, M. L., Van Der Schueren, B. J., Ahren, B., Wang, G. C., Swerdlow, N. J., Arias, S., Bose, M., Gorroochurn, P., Teixeira, J., McGinty, J., & Laferrère, B. (2011). Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 13(4), 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x