Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam, B. J. Van Der Schueren, B. Ahren, G. C. Wang, N. J. Swerdlow, S. Arias, Mousumi Bose, P. Gorroochurn, J. Teixeira, J. McGinty, B. Laferrère

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Abstract

The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalDiabetes, Obesity and Metabolism
Volume13
Issue number4
DOIs
StatePublished - 1 Jan 2011

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Dipeptidyl Peptidase 4
Caloric Restriction
Gastric Bypass
Type 2 Diabetes Mellitus
Incretins
Weight Loss
Fasting
Glucose
Glucagon-Like Peptide 1
Insulin
Peptides
Enzymes

Keywords

  • Dipeptidyl peptidase inhibitor
  • GLP-1
  • Gastric bypass
  • Weight loss

Cite this

Alam, M. L. ; Van Der Schueren, B. J. ; Ahren, B. ; Wang, G. C. ; Swerdlow, N. J. ; Arias, S. ; Bose, Mousumi ; Gorroochurn, P. ; Teixeira, J. ; McGinty, J. ; Laferrère, B. / Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes. In: Diabetes, Obesity and Metabolism. 2011 ; Vol. 13, No. 4. pp. 378-381.
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Alam, ML, Van Der Schueren, BJ, Ahren, B, Wang, GC, Swerdlow, NJ, Arias, S, Bose, M, Gorroochurn, P, Teixeira, J, McGinty, J & Laferrère, B 2011, 'Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes', Diabetes, Obesity and Metabolism, vol. 13, no. 4, pp. 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x

Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes. / Alam, M. L.; Van Der Schueren, B. J.; Ahren, B.; Wang, G. C.; Swerdlow, N. J.; Arias, S.; Bose, Mousumi; Gorroochurn, P.; Teixeira, J.; McGinty, J.; Laferrère, B.

In: Diabetes, Obesity and Metabolism, Vol. 13, No. 4, 01.01.2011, p. 378-381.

Research output: Contribution to journalLetterResearchpeer-review

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T1 - Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

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AU - Van Der Schueren, B. J.

AU - Ahren, B.

AU - Wang, G. C.

AU - Swerdlow, N. J.

AU - Arias, S.

AU - Bose, Mousumi

AU - Gorroochurn, P.

AU - Teixeira, J.

AU - McGinty, J.

AU - Laferrère, B.

PY - 2011/1/1

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N2 - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

AB - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

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KW - Weight loss

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DO - 10.1111/j.1463-1326.2011.01358.x

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