Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam; B. J. Van Der Schueren; B. Ahren; G. C. Wang; N. J. Swerdlow; S. Arias; M. Bose; P. Gorroochurn; J. Teixeira; J. McGinty; B. Laferrère

doi:10.1111/j.1463-1326.2011.01358.x

Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

M. L. Alam
, B. J. Van Der Schueren
, B. Ahren
, G. C. Wang
, N. J. Swerdlow
, S. Arias
, M. Bose
, P. Gorroochurn
, J. Teixeira
, J. McGinty
, B. Laferrère

Nutrition and Food Studies

Research output: Contribution to journal › Letter › peer-review

34 Scopus citations

Abstract

The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

Original language	English
Pages (from-to)	378-381
Number of pages	4
Journal	Diabetes, Obesity and Metabolism
Volume	13
Issue number	4
DOIs	https://doi.org/10.1111/j.1463-1326.2011.01358.x
State	Published - Apr 2011

Keywords

Dipeptidyl peptidase inhibitor
GLP-1
Gastric bypass
Weight loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1463-1326.2011.01358.x

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Alam, M. L., Van Der Schueren, B. J., Ahren, B., Wang, G. C., Swerdlow, N. J., Arias, S., Bose, M., Gorroochurn, P., Teixeira, J., McGinty, J., & Laferrère, B. (2011). Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 13(4), 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x

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title = "Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes",

abstract = "The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6\% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.",

keywords = "Dipeptidyl peptidase inhibitor, GLP-1, Gastric bypass, Weight loss",

author = "Alam, \{M. L.\} and \{Van Der Schueren\}, \{B. J.\} and B. Ahren and Wang, \{G. C.\} and Swerdlow, \{N. J.\} and S. Arias and M. Bose and P. Gorroochurn and J. Teixeira and J. McGinty and B. Laferr{\`e}re",

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doi = "10.1111/j.1463-1326.2011.01358.x",

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Alam, ML, Van Der Schueren, BJ, Ahren, B, Wang, GC, Swerdlow, NJ, Arias, S, Bose, M, Gorroochurn, P, Teixeira, J, McGinty, J & Laferrère, B 2011, 'Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes', Diabetes, Obesity and Metabolism, vol. 13, no. 4, pp. 378-381. https://doi.org/10.1111/j.1463-1326.2011.01358.x

TY - JOUR

T1 - Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

AU - Alam, M. L.

AU - Van Der Schueren, B. J.

AU - Ahren, B.

AU - Wang, G. C.

AU - Swerdlow, N. J.

AU - Arias, S.

AU - Bose, M.

AU - Gorroochurn, P.

AU - Teixeira, J.

AU - McGinty, J.

AU - Laferrère, B.

PY - 2011/4

Y1 - 2011/4

N2 - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

AB - The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass (GBP) surgery is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10-kg equivalent weight loss by GBP (n = 16) or by caloric restriction (CR,n = 14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p = 0.01), but not after CR. The increased peak glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretin concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.

KW - Dipeptidyl peptidase inhibitor

KW - GLP-1

KW - Gastric bypass

KW - Weight loss

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DO - 10.1111/j.1463-1326.2011.01358.x

M3 - Letter

C2 - 21210936

AN - SCOPUS:79951868952

SN - 1462-8902

VL - 13

SP - 378

EP - 381

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 4

ER -

Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes

Abstract

Keywords

UN SDGs

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