Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

Carolyn A. Worby, Quinn C. Vega, Yi Zhao, Hanna H.J. Chao, Audrey F. Seasholtz, Jack E. Dixon

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β family of growth factors, was first identified by its ability to promote the survival of midbrain dopaminergic neurons in culture. We demonstrate that GDNF treatment of several neuroblastoma cell lines leads to dose-dependent tyrosine phosphorylation of the RET receptor and that other transforming growth factor-β family members are not able to activate the RET receptor. GDNF treatment of neuroblastoma cells also results in increased transcription of an Elk luciferase reporter gene, suggesting that GDNF activates the mitogen-activated protein kinase signal transduction pathway.

Original languageEnglish
Pages (from-to)23619-23622
Number of pages4
JournalJournal of Biological Chemistry
Volume271
Issue number39
DOIs
StatePublished - 10 Oct 1996

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