Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms

Waleed Brinjikji, Bong Jae Chung, Ding Yong-Hong, John T. Wald, Fernando Mut, Ramanathan Kadirvel, David F. Kallmes, Aymeric Rouchaud, Giuseppe Lanzino, Juan R. Cebral

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. Image based computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups (stable vs unstable and no stroke vs stroke) using the Wilcoxon test. Results A total of 37 VBDAs were included (24 stable, 13 unstable; 30 no stroke, 7 stroke). Unstable aneurysms had lower shear rates (P=0.05), blood flow velocity (P=0.03), and lower vorticity (P=0.049) than stable aneurysms. In addition, unstable aneurysms had higher mean oscillatory shear indices (P=0.001). There were no differences in the hemodynamic characteristics of aneurysms in the stroke group compared with the non-stroke group. Conclusion This small study suggests there may be hemodynamic differences between unstable and stable VBDAs. Unstable VBDAs appear to be under lower flow conditions with lower velocity, vorticity, and shear rates, and have more oscillatory flow. There was no difference in the hemodynamic characteristics of aneurysms in the stroke and no stroke group.

Original languageEnglish
Pages (from-to)1102-1107
Number of pages6
JournalJournal of NeuroInterventional Surgery
Volume10
Issue number11
DOIs
StatePublished - 1 Nov 2018

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Aneurysm
Hemodynamics
Stroke
Rupture
Pulsatile Flow
Blood Flow Velocity
Hydrodynamics
Growth
Natural History
Comorbidity
Angiography
Demography

Keywords

  • aneurysm
  • computational fluid dynamics
  • hemodynamics

Cite this

Brinjikji, Waleed ; Chung, Bong Jae ; Yong-Hong, Ding ; Wald, John T. ; Mut, Fernando ; Kadirvel, Ramanathan ; Kallmes, David F. ; Rouchaud, Aymeric ; Lanzino, Giuseppe ; Cebral, Juan R. / Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms. In: Journal of NeuroInterventional Surgery. 2018 ; Vol. 10, No. 11. pp. 1102-1107.
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title = "Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms",
abstract = "Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. Image based computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups (stable vs unstable and no stroke vs stroke) using the Wilcoxon test. Results A total of 37 VBDAs were included (24 stable, 13 unstable; 30 no stroke, 7 stroke). Unstable aneurysms had lower shear rates (P=0.05), blood flow velocity (P=0.03), and lower vorticity (P=0.049) than stable aneurysms. In addition, unstable aneurysms had higher mean oscillatory shear indices (P=0.001). There were no differences in the hemodynamic characteristics of aneurysms in the stroke group compared with the non-stroke group. Conclusion This small study suggests there may be hemodynamic differences between unstable and stable VBDAs. Unstable VBDAs appear to be under lower flow conditions with lower velocity, vorticity, and shear rates, and have more oscillatory flow. There was no difference in the hemodynamic characteristics of aneurysms in the stroke and no stroke group.",
keywords = "aneurysm, computational fluid dynamics, hemodynamics",
author = "Waleed Brinjikji and Chung, {Bong Jae} and Ding Yong-Hong and Wald, {John T.} and Fernando Mut and Ramanathan Kadirvel and Kallmes, {David F.} and Aymeric Rouchaud and Giuseppe Lanzino and Cebral, {Juan R.}",
year = "2018",
month = "11",
day = "1",
doi = "10.1136/neurintsurg-2018-013756",
language = "English",
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Brinjikji, W, Chung, BJ, Yong-Hong, D, Wald, JT, Mut, F, Kadirvel, R, Kallmes, DF, Rouchaud, A, Lanzino, G & Cebral, JR 2018, 'Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms', Journal of NeuroInterventional Surgery, vol. 10, no. 11, pp. 1102-1107. https://doi.org/10.1136/neurintsurg-2018-013756

Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms. / Brinjikji, Waleed; Chung, Bong Jae; Yong-Hong, Ding; Wald, John T.; Mut, Fernando; Kadirvel, Ramanathan; Kallmes, David F.; Rouchaud, Aymeric; Lanzino, Giuseppe; Cebral, Juan R.

In: Journal of NeuroInterventional Surgery, Vol. 10, No. 11, 01.11.2018, p. 1102-1107.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms

AU - Brinjikji, Waleed

AU - Chung, Bong Jae

AU - Yong-Hong, Ding

AU - Wald, John T.

AU - Mut, Fernando

AU - Kadirvel, Ramanathan

AU - Kallmes, David F.

AU - Rouchaud, Aymeric

AU - Lanzino, Giuseppe

AU - Cebral, Juan R.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. Image based computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups (stable vs unstable and no stroke vs stroke) using the Wilcoxon test. Results A total of 37 VBDAs were included (24 stable, 13 unstable; 30 no stroke, 7 stroke). Unstable aneurysms had lower shear rates (P=0.05), blood flow velocity (P=0.03), and lower vorticity (P=0.049) than stable aneurysms. In addition, unstable aneurysms had higher mean oscillatory shear indices (P=0.001). There were no differences in the hemodynamic characteristics of aneurysms in the stroke group compared with the non-stroke group. Conclusion This small study suggests there may be hemodynamic differences between unstable and stable VBDAs. Unstable VBDAs appear to be under lower flow conditions with lower velocity, vorticity, and shear rates, and have more oscillatory flow. There was no difference in the hemodynamic characteristics of aneurysms in the stroke and no stroke group.

AB - Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. Image based computational fluid dynamics models were created and run under pulsatile flow conditions. Relevant hemodynamic and geometric variables were calculated and compared between groups (stable vs unstable and no stroke vs stroke) using the Wilcoxon test. Results A total of 37 VBDAs were included (24 stable, 13 unstable; 30 no stroke, 7 stroke). Unstable aneurysms had lower shear rates (P=0.05), blood flow velocity (P=0.03), and lower vorticity (P=0.049) than stable aneurysms. In addition, unstable aneurysms had higher mean oscillatory shear indices (P=0.001). There were no differences in the hemodynamic characteristics of aneurysms in the stroke group compared with the non-stroke group. Conclusion This small study suggests there may be hemodynamic differences between unstable and stable VBDAs. Unstable VBDAs appear to be under lower flow conditions with lower velocity, vorticity, and shear rates, and have more oscillatory flow. There was no difference in the hemodynamic characteristics of aneurysms in the stroke and no stroke group.

KW - aneurysm

KW - computational fluid dynamics

KW - hemodynamics

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U2 - 10.1136/neurintsurg-2018-013756

DO - 10.1136/neurintsurg-2018-013756

M3 - Article

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SP - 1102

EP - 1107

JO - Journal of NeuroInterventional Surgery

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SN - 1759-8478

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