Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism

Gennady N. Smagin, Dekun Song, David P. Budac, Jessica A. Waller, Yan Li, Alan Pehrson, Connie Sánchez

Research output: Contribution to journalShort surveyResearchpeer-review

4 Citations (Scopus)

Abstract

Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HT transporter inhibitor in vitro. In preclinical and clinical studies vortioxetine demonstrates positive effects on cognitive dysfunction. Vortioxetine's effect on cognitive function likely involves the modulation of several neurotransmitter systems. Acute and chronic administration of vortioxetine resulted in changes in histamine concentrations in microdialysates collected from the rat prefrontal cortex and ventral hippocampus. Based on these results and a literature review of the current understanding of the interaction between the histaminergic and serotonergic systems and the role of histamine on cognitive function, we hypothesize that vortioxetine through an activation of the orexinergic system stimulates the tuberomammilary nucleus and enhances histaminergic neurotransmission, which contributes to vortioxetine's positive effects on cognitive function.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume68
DOIs
StatePublished - 4 Jul 2016

Fingerprint

Histamine
Cognition
Serotonin
Receptor, Serotonin, 5-HT1D
Serotonin 5-HT1 Receptor Antagonists
Receptor, Serotonin, 5-HT1B
Serotonin 5-HT1 Receptor Agonists
Receptor, Serotonin, 5-HT1A
Prefrontal Cortex
Synaptic Transmission
Antidepressive Agents
Neurotransmitter Agents
vortioxetine
Hippocampus

Keywords

  • 5-HT receptors
  • Antidepressant
  • Cognition
  • Histamine

Cite this

Smagin, Gennady N. ; Song, Dekun ; Budac, David P. ; Waller, Jessica A. ; Li, Yan ; Pehrson, Alan ; Sánchez, Connie. / Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2016 ; Vol. 68. pp. 25-30.
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abstract = "Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HT transporter inhibitor in vitro. In preclinical and clinical studies vortioxetine demonstrates positive effects on cognitive dysfunction. Vortioxetine's effect on cognitive function likely involves the modulation of several neurotransmitter systems. Acute and chronic administration of vortioxetine resulted in changes in histamine concentrations in microdialysates collected from the rat prefrontal cortex and ventral hippocampus. Based on these results and a literature review of the current understanding of the interaction between the histaminergic and serotonergic systems and the role of histamine on cognitive function, we hypothesize that vortioxetine through an activation of the orexinergic system stimulates the tuberomammilary nucleus and enhances histaminergic neurotransmission, which contributes to vortioxetine's positive effects on cognitive function.",
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Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. / Smagin, Gennady N.; Song, Dekun; Budac, David P.; Waller, Jessica A.; Li, Yan; Pehrson, Alan; Sánchez, Connie.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 68, 04.07.2016, p. 25-30.

Research output: Contribution to journalShort surveyResearchpeer-review

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AU - Smagin, Gennady N.

AU - Song, Dekun

AU - Budac, David P.

AU - Waller, Jessica A.

AU - Li, Yan

AU - Pehrson, Alan

AU - Sánchez, Connie

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AB - Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HT transporter inhibitor in vitro. In preclinical and clinical studies vortioxetine demonstrates positive effects on cognitive dysfunction. Vortioxetine's effect on cognitive function likely involves the modulation of several neurotransmitter systems. Acute and chronic administration of vortioxetine resulted in changes in histamine concentrations in microdialysates collected from the rat prefrontal cortex and ventral hippocampus. Based on these results and a literature review of the current understanding of the interaction between the histaminergic and serotonergic systems and the role of histamine on cognitive function, we hypothesize that vortioxetine through an activation of the orexinergic system stimulates the tuberomammilary nucleus and enhances histaminergic neurotransmission, which contributes to vortioxetine's positive effects on cognitive function.

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