ICER-IIγ is a tumor suppressor that mediates the antiproliferative activity of cAMP

Reza Razavi, Juan C. Ramos, Ghassan Yehia, Florence Schlotter, Carlos A. Molina

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIγ (ICER-IIγ), is induced by cAMP. ICER-IIγ blocks cells at the G2/M boundary of the cell cycle. Here we show that ICER-IIγ dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells. This alteration in cell growth is coupled with reduced ability of these cells to grow in an anchorage-independent manner and to form tumors in mice. These data demonstrate that ICER-IIγ is a tumor suppressor gene product mediating the antiproliferative activity of cAMP.

Original languageEnglish
Pages (from-to)3015-3019
Number of pages5
JournalOncogene
Volume17
Issue number23
DOIs
StatePublished - 10 Dec 1998

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Keywords

  • CREM
  • ICER-IIγ
  • Tumor suppressor
  • cAMP

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