Individual Differences in Working Memory Capacity Predicts Responsiveness to Memory Rehabilitation After Traumatic Brain Injury

Joshua Sandry, Kathy S. Chiou, John DeLuca, Nancy D. Chiaravalloti

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7 Citations (Scopus)

Abstract

Objective To explore how individual differences affect rehabilitation outcomes by specifically investigating whether working memory capacity (WMC) can be used as a cognitive marker to identify who will and will not improve from memory rehabilitation. Design Post hoc analysis of a randomized controlled clinical trial designed to treat learning and memory impairment after traumatic brain injury (TBI): 2 × 2 between-subjects quasiexperimental design (2 [group: treatment vs control] × 2 [WMC: high vs low]). Setting Nonprofit medical rehabilitation research center. Participants Participants (N=65) with moderate to severe TBI with pre- and posttreatment data. Interventions The treatment group completed 10 cognitive rehabilitation sessions in which subjects were taught a memory strategy focusing on learning to use context and imagery to remember information. The placebo control group engaged in active therapy sessions that did not involve learning the memory strategy. Main Outcome Measure Long-term memory percent retention change scores for an unorganized list of words from the California Verbal Learning Test-II. Results Group and WMC interacted (P=.008, ηp 2=.12). High WMC participants showed a benefit from treatment compared with low WMC participants. Individual differences in WMC accounted for 45% of the variance in whether participants with TBI in the treatment group benefited from applying the compensatory treatment strategy to learn unorganized information. Conclusions Individuals with higher WMC showed a significantly greater rehabilitation benefit when applying the compensatory strategy to learn unorganized information. WMC is a useful cognitive marker for identifying participants with TBI who respond to memory rehabilitation with the modified Story Memory Technique.

Original languageEnglish
Pages (from-to)1026-1029.e1
JournalArchives of Physical Medicine and Rehabilitation
Volume97
Issue number6
DOIs
StatePublished - 1 Jun 2016

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Short-Term Memory
Individuality
Rehabilitation
Learning
Therapeutics
Verbal Learning
Rehabilitation Centers
Long-Term Memory
Traumatic Brain Injury
Imagery (Psychotherapy)
Biomedical Research
Randomized Controlled Trials
Placebos
Outcome Assessment (Health Care)
Control Groups

Keywords

  • Brain injuries
  • Cognition
  • Memory Disorders
  • Neurology
  • Rehabilitation

Cite this

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title = "Individual Differences in Working Memory Capacity Predicts Responsiveness to Memory Rehabilitation After Traumatic Brain Injury",
abstract = "Objective To explore how individual differences affect rehabilitation outcomes by specifically investigating whether working memory capacity (WMC) can be used as a cognitive marker to identify who will and will not improve from memory rehabilitation. Design Post hoc analysis of a randomized controlled clinical trial designed to treat learning and memory impairment after traumatic brain injury (TBI): 2 × 2 between-subjects quasiexperimental design (2 [group: treatment vs control] × 2 [WMC: high vs low]). Setting Nonprofit medical rehabilitation research center. Participants Participants (N=65) with moderate to severe TBI with pre- and posttreatment data. Interventions The treatment group completed 10 cognitive rehabilitation sessions in which subjects were taught a memory strategy focusing on learning to use context and imagery to remember information. The placebo control group engaged in active therapy sessions that did not involve learning the memory strategy. Main Outcome Measure Long-term memory percent retention change scores for an unorganized list of words from the California Verbal Learning Test-II. Results Group and WMC interacted (P=.008, ηp 2=.12). High WMC participants showed a benefit from treatment compared with low WMC participants. Individual differences in WMC accounted for 45{\%} of the variance in whether participants with TBI in the treatment group benefited from applying the compensatory treatment strategy to learn unorganized information. Conclusions Individuals with higher WMC showed a significantly greater rehabilitation benefit when applying the compensatory strategy to learn unorganized information. WMC is a useful cognitive marker for identifying participants with TBI who respond to memory rehabilitation with the modified Story Memory Technique.",
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Individual Differences in Working Memory Capacity Predicts Responsiveness to Memory Rehabilitation After Traumatic Brain Injury. / Sandry, Joshua; Chiou, Kathy S.; DeLuca, John; Chiaravalloti, Nancy D.

In: Archives of Physical Medicine and Rehabilitation, Vol. 97, No. 6, 01.06.2016, p. 1026-1029.e1.

Research output: Contribution to journalArticleResearchpeer-review

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