Information theoretical approach to single-molecule experimental design and interpretation

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We use Shannon's definition of information to develop a theory to predict a photon-counting-based single-molecule experiment's ability to measure the desired property. We treat three phenomena that are commonly measured on single molecules: spectral fluctuations of a solvatochromic dye; assignment of the azimuthal dipole angle; determination of a distance by fluorescence resonant energy transfer using Förster's theory. We consider the effect of background and other "imperfections" on the measurement through the decrease in information.

Original languageEnglish
Pages (from-to)9743-9757
Number of pages15
JournalJournal of Physical Chemistry A
Volume110
Issue number31
DOIs
StatePublished - 10 Aug 2006

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Design of experiments
Molecules
Energy transfer
molecules
counting
Coloring Agents
Photons
dyes
Fluorescence
energy transfer
dipoles
fluorescence
Defects
defects
photons
Experiments

Cite this

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Information theoretical approach to single-molecule experimental design and interpretation. / Talaga, David S.

In: Journal of Physical Chemistry A, Vol. 110, No. 31, 10.08.2006, p. 9743-9757.

Research output: Contribution to journalArticle

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