Information theoretical approach to single-molecule experimental design and interpretation

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Abstract

We use Shannon's definition of information to develop a theory to predict a photon-counting-based single-molecule experiment's ability to measure the desired property. We treat three phenomena that are commonly measured on single molecules: spectral fluctuations of a solvatochromic dye; assignment of the azimuthal dipole angle; determination of a distance by fluorescence resonant energy transfer using Förster's theory. We consider the effect of background and other "imperfections" on the measurement through the decrease in information.

Original languageEnglish
Pages (from-to)9743-9757
Number of pages15
JournalJournal of Physical Chemistry A
Volume110
Issue number31
DOIs
StatePublished - 10 Aug 2006

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