Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil

Mousumi Bose, Xingpei Hao, Jihyeung Ju, Ali Husain, Sunny Park, Joshua D. Lambert, Chung S. Yang

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in ApcMin/+ mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. β-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E2 (PGE2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in ApcMin/+ mice.

Original languageEnglish
Pages (from-to)7695-7700
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume55
Issue number19
DOIs
StatePublished - 19 Sep 2007

Fingerprint

Fish Oils
epigallocatechin
fish oils
carcinogenesis
Carcinogenesis
mice
Tumors
adenoma
Adenoma
neoplasms
apoptosis
Modulation
Apoptosis
Catenins
Neoplasms
Phosphorylation
High Fat Diet
high fat diet
Nutrition
arachidonic acid

Keywords

  • (-)-Epigallocatechin gallate
  • Apc mouse
  • Fish oil
  • Intestinal cancer

Cite this

Bose, Mousumi ; Hao, Xingpei ; Ju, Jihyeung ; Husain, Ali ; Park, Sunny ; Lambert, Joshua D. ; Yang, Chung S. / Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. In: Journal of Agricultural and Food Chemistry. 2007 ; Vol. 55, No. 19. pp. 7695-7700.
@article{ac3f689090d7478eacce0518e033dccf,
title = "Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil",
abstract = "The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in ApcMin/+ mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53{\%} as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. β-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E2 (PGE2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in ApcMin/+ mice.",
keywords = "(-)-Epigallocatechin gallate, Apc mouse, Fish oil, Intestinal cancer",
author = "Mousumi Bose and Xingpei Hao and Jihyeung Ju and Ali Husain and Sunny Park and Lambert, {Joshua D.} and Yang, {Chung S.}",
year = "2007",
month = "9",
day = "19",
doi = "10.1021/jf071004r",
language = "English",
volume = "55",
pages = "7695--7700",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "19",

}

Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. / Bose, Mousumi; Hao, Xingpei; Ju, Jihyeung; Husain, Ali; Park, Sunny; Lambert, Joshua D.; Yang, Chung S.

In: Journal of Agricultural and Food Chemistry, Vol. 55, No. 19, 19.09.2007, p. 7695-7700.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil

AU - Bose, Mousumi

AU - Hao, Xingpei

AU - Ju, Jihyeung

AU - Husain, Ali

AU - Park, Sunny

AU - Lambert, Joshua D.

AU - Yang, Chung S.

PY - 2007/9/19

Y1 - 2007/9/19

N2 - The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in ApcMin/+ mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. β-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E2 (PGE2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in ApcMin/+ mice.

AB - The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in ApcMin/+ mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. β-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E2 (PGE2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in ApcMin/+ mice.

KW - (-)-Epigallocatechin gallate

KW - Apc mouse

KW - Fish oil

KW - Intestinal cancer

UR - http://www.scopus.com/inward/record.url?scp=34948844451&partnerID=8YFLogxK

U2 - 10.1021/jf071004r

DO - 10.1021/jf071004r

M3 - Article

VL - 55

SP - 7695

EP - 7700

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 19

ER -