Intake of coffee and tea and risk of ovarian cancer

A prospective cohort study

Stephanie Silvera, Meera Jain, Geoffrey R. Howe, Anthony B. Miller, Thomas E. Rohan

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

There is some evidence from case-control studies that coffee consumption might be positively associated with ovarian cancer risk, whereas the epidemiologic evidence regarding tea consumption and ovarian cancer is inconsistent. To date, there have been few prospective studies of these associations. Therefore, we examined ovarian cancer risk in association with both coffee and tea intake in a prospective cohort study of 49,613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food frequency questionnaire between 1980 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000. Data from the food frequency questionnaire were used to estimate daily intake of coffee and tea. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between categories of coffee and tea intake and ovarian cancer risk. During a mean 16.4 years of follow-up, we observed 264 incident ovarian cancer cases. Tea intake was not associated with ovarian cancer risk in our study population. In contrast, a borderline positive association was observed among women who drank >4 cups coffee/day compared to women who did not drink coffee (HR = 1.62, 95% CI = 0.95-2.75, P trend = 0.06). Given the pervasive use of these beverages, the associations between coffee and tea consumption and ovarian cancer risk warrant investigation in further prospective studies.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalNutrition and Cancer
Volume58
Issue number1
DOIs
StatePublished - 1 Jan 2007

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Coffee
Tea
Ovarian Neoplasms
Cohort Studies
Prospective Studies
Confidence Intervals
Food
Beverages
Proportional Hazards Models
Case-Control Studies
Neoplasms
Breast
Databases
Mortality
Incidence
Population

Cite this

Silvera, Stephanie ; Jain, Meera ; Howe, Geoffrey R. ; Miller, Anthony B. ; Rohan, Thomas E. / Intake of coffee and tea and risk of ovarian cancer : A prospective cohort study. In: Nutrition and Cancer. 2007 ; Vol. 58, No. 1. pp. 22-27.
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Intake of coffee and tea and risk of ovarian cancer : A prospective cohort study. / Silvera, Stephanie; Jain, Meera; Howe, Geoffrey R.; Miller, Anthony B.; Rohan, Thomas E.

In: Nutrition and Cancer, Vol. 58, No. 1, 01.01.2007, p. 22-27.

Research output: Contribution to journalArticleResearchpeer-review

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